Naltrexone effects on cortisol secretion in women and men in relation to a family history of alcoholism: studies from the Oklahoma Family Health Patterns Project.

Psychoneuroendocrinology
William R LovalloAndrea S Vincent

Abstract

Naltrexone evokes a cortisol response through its blockade of central opioid receptors on the hypothalamic-pituitary-adrenocortical axis (HPA). The magnitude of this cortisol response may be useful as a probe for central opioid activity in different groups of subjects. Accordingly, the present study examined the effect of opioid blockade on the HPA in 70 women and 58 men with (N=41) and without (N=87) a family history of alcoholism, using a randomized, placebo-controlled, double blind administration of oral naltrexone (50mg). Saliva cortisol was sampled at baseline prior to placebo or naltrexone and again every 30 min over the next 180 min. Women had significantly larger cortisol responses to naltrexone than did the men, F=6.88, p<0.0001. There were no significant differences in cortisol response between groups differing in family history of alcoholism, F=0.65, p>0.69. The present results confirm that women have much greater central opioid restraint on the HPA than men do and that this endogenous restraint is unmasked by opioid blockade. However the results provide no evidence of a differential central opioid tonus in persons with a family history of alcoholism at this dose of naltrexone. The cortisol response to naltrexone may...Continue Reading

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Citations

May 16, 2013·Pharmacology, Biochemistry, and Behavior·Daniel J O RocheWilliam R Lovallo
Oct 16, 2013·Peptides·Richard J Bodnar
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Aug 16, 2016·Clinics in Laboratory Medicine·Rif S El-MallakhKristen K Reynolds
Jul 6, 2018·European Journal of Endocrinology·Athanasios FountasNiki Karavitaki
Sep 16, 2020·Stress : the International Journal on the Biology of Stress·Mustafa al'AbsiSharon Allen
Mar 2, 2017·Alcoholism, Clinical and Experimental Research·Shantrel S CanidateRobert L Cook
Dec 22, 2017·Journal of the Endocrine Society·Rebecca J GordonSharon L Wardlaw
Oct 10, 2018·European Journal of Endocrinology·Athanasios FountasNiki Karavitaki
Jul 24, 2021·Psychosomatic Medicine·Anna C WhittakerWilliam R Lovallo

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