PMID: 10607087Sep 1, 1993Paper

Naltrexone improves blood gas patterns in obstructive sleep apnoea syndrome through its influence on sleep

Journal of Sleep Research
C FerberJ Mouret


Endogenous opiates have been shown to depress ventilation, and could therefore play a role in sleep apnoea syndrome (SAS). Hence, opiate antagonists have been used to treat SAS. The improvement they seem to give in blood-gas monitoring could derive either from a direct blocking of endorphins that inhibit respiration or else, indirectly, through an influence on sleep patterns. The present study used a double blind cross-over protocol to investigate the relationships between the effects on blood-gas and on sleep patterns of the oral opiate antagonist naltrexone in obstructive SAS. Sleep patterns and transcutaneous blood gas (tcPO2 and tcPCO2) were recorded in parallel. Control recordings, without treatment, were carried out over two nights, followed by two nights of recording after administration either of naltrexone followed by a placebo or of a placebo followed by naltrexone. The number of obstructive apnoea and hypopnoea events per hour of sleep (Apnoea-Hypopnoea Index: AHI), of hypoxic events (defined as a tcPO2 fall of at least 10, 15 or 20 mm Hg) and of hypercapnic events (defined as a tcPCO2 increase of at least 5 mm Hg) were counted. A Metabolic Suffering Index (MSI) was calculated, defined as the product of the number, d...Continue Reading


Sep 25, 1978·Life Sciences·I R Moss, E Friedman
Mar 1, 1992·Chest·E Mulloy, W T McNicholas
Jun 1, 1991·The American Review of Respiratory Disease·H E GreenbergRoberta M Goldring
Oct 1, 1990·The American Review of Respiratory Disease·J E ShookE M Camporesi
Mar 1, 1990·Chest·J E Remmers
Jan 1, 1988·Chest·S B Reents, C A Beck
Jan 1, 1988·Annales Françaises D'anesthèsie Et De Rèanimation·J ManchonM Gallet
Dec 1, 1987·Chest·J S Wagener, C Hendricker
Aug 31, 1973·Science·Christian GuilleminaultW C Dement
Jan 1, 1983·British Medical Bulletin·D S McQueen
Apr 27, 1981·Brain Research·M PokorskiJ Wideman
Sep 1, 1982·Critical Care Medicine·J P OrlowskiD S Moodie
Jul 29, 1982·Brain Research·N Sitaram, J C Gillin
Jan 1, 1984·Psychopharmacology·C CianchettiG Giordano
Oct 21, 1982·The New England Journal of Medicine·L G BrownellM H Kryger
Mar 27, 1982·British Medical Journal·J AyresG M Cochrane
Jun 5, 1982·British Medical Journal
Jan 1, 1983·The American Review of Respiratory Disease·P L SmithE R Bleecker
Jan 1, 1982·Thorax·W A ConwayT Roth
Jan 1, 1980·Sleep·Christian Guilleminault
Jan 1, 1980·Sleep·C E Sullivan, F G Issa


Jan 1, 1994·Peptides·G A OlsonA J Kastin
Feb 14, 2013·Behavioural and Cognitive Psychotherapy·Markus Jansson-Fröjmark
Jun 30, 2012·Behavioral Sleep Medicine·Julie A WoosleyAndrew J Bush
Oct 16, 2002·American Journal of Respiratory and Critical Care Medicine·Indu AyappaRoberta M Goldring
Apr 2, 2005·Behavioral Sleep Medicine·Thomas J CareyDaniel J Buysse
Sep 30, 2005·Behavioral Sleep Medicine·Victor I SpoormakerEd C Klip
Aug 27, 2014·Clinics in Chest Medicine·Gilbert SedaTeofilo Lee-Chiong
May 1, 2008·Expert Review of Clinical Pharmacology·Jonathan Rl SchwartzTom Roth
Dec 24, 2005·Expert Opinion on Pharmacotherapy·Vivien C Abad, Christian Guilleminault
Jun 4, 2011·Expert Opinion on Investigational Drugs·Malcolm Kohler, John R Stradling
Apr 25, 2009·Expert Opinion on Investigational Drugs·Malcolm KohlerJohn R Stradling
Oct 27, 2012·Neurologic Clinics·Octavian C Ioachimescu, Nancy A Collop
Jan 19, 2008·Sleep Medicine Reviews·Jan HednerDing Zou
Feb 27, 2018·British Journal of Clinical Pharmacology·Charles KhouriRenaud Tamisier
Sep 18, 1997·Journal of Clinical Child Psychology·D E Hansen, B Vandenberg
Dec 19, 2013·Journal of Clinical Psychopharmacology·John SramekNeal R Cutler
Jun 4, 2013·The Cochrane Database of Systematic Reviews·Martina MasonIan Smith
Oct 14, 2016·British Journal of Clinical Pharmacology·Ingrid Jullian-DesayesMarie Joyeux-Faure

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.