Naming is associated with left temporal pole metabolite levels in neurodegenerative diseases

Dementia and Geriatric Cognitive Disorders
Lorena RamiJosé L Molinuevo

Abstract

To investigate the relationship between performance in language tests and levels of brain metabolites in two selected left temporal lobe regions. Ninety-five subjects were included: 26 controls, 30 amnestic mild cognitive impairment subjects, 27 Alzheimer's disease and 12 frontotemporal lobar degeneration (FTLD) patients. Language was assessed by a naming test: Boston Naming Test (BNT) and by a semantic verbal fluency test. Other cognitive functions: verbal and visual memory, visual perception, attention and executive function, and praxis were also assessed. Single voxel magnetic resonance spectroscopy was obtained in the left temporal pole (L-TPOLE), and in the left posterior temporoparietal region (L-TPAR). BNT scores were significantly associated with N-acetylaspartate/creatine ratios (r = 0.45; p < 0.001) and choline/creatine ratios (r = 0.33; p < 0.005) in the L-TPOLE. No significant associations were found between BNT and metabolite levels in the L-TPAR. No significant associations were found between the semantic verbal fluency test and other cognitive tests and metabolite levels either in the L-TPOLE or in the L-TPAR. Naming performance is related to metabolite levels in the anterior L-TPOLE.

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Citations

Oct 23, 2010·Journal of Cognitive Neuroscience·Andrea B Protzner, Mary Pat McAndrews
Oct 2, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Yaroslau ComptaEduardo Tolosa
Aug 24, 2013·Neuroscience and Biobehavioral Reviews·Shankar TumatiAndré Aleman
Jan 15, 2009·Journal of Clinical and Experimental Neuropsychology·Montse AlegretLluís Tárraga

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