NAMPT: A pleiotropic modulator of monocytes and macrophages

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Cristina TravelliChiara Porta

Abstract

Nicotinamide phosphoribosyltransferase (NAMPT) is the bottleneck enzyme of the NAD salvage pathway and thereby is a controller of intracellular NAD concentrations. It has been long known that the same enzyme can be secreted by a number of cell types and acts as a cytokine, although its receptor is at present unknown. Investigational compounds have been developed that target the enzymatic activity as well as the extracellular action (i.e. neutralizing antibodies). The present contribution reviews the evidence that links intracellular and extracellular NAMPT to myeloid biology, for example governing monocyte/macrophage differentiation, polarization and migration. Furthermore, it reviews the evidence that links this protein to some disorders in which myeloid cells have a prominent role (acute infarct, inflammatory bowel disease, acute lung injury and rheumatoid arthritis) and the data showing that inhibition of the enzymatic activity or the neutralization of the cytokine is beneficial in preclinical animal models.

Citations

Apr 28, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Giorgia ColomboCristina Travelli
Aug 22, 2020·World Journal of Gastroenterology : WJG·Gabriel Benyomo MpillaAsfar Sohail Azmi
Apr 9, 2020·Frontiers in Oncology·Valentina AudritoSilvia Deaglio
Jun 2, 2020·Frontiers in Pharmacology·Ubaldina GalliAmbra A Grolla
Nov 14, 2019·International Journal of Molecular Sciences·Elena SiakaevaJadwiga Jablonska
Dec 3, 2020·International Journal of Molecular Sciences·Dóra KovácsDániel Törőcsik
Mar 14, 2021·Neurochemical Research·Yaling XuXijin Wang
Jun 30, 2021·Trends in Cancer·Lin XiaoKlaartje Somers
May 10, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rui WangWei Wei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.