Nandrolone abuse decreases anxiety and impairs memory in rats via central androgenic receptors

The International Journal of Neuropsychopharmacology
Dimitrios KouvelasMichaela M Kraus

Abstract

Anabolic androgenic steroids (AASs) affect areas of the central nervous system, which are involved in emotional and cognitive responses such as sexuality, anxiety, and memory. In the present study we imitated the abuse of AASs by administering high doses of the AAS nandrolone decanoate (ND) to rats. Thereafter rats were exposed to an elevated plus-maze and an olfactory social memory test to evaluate their anxiety-like and cognitive behaviour. To reveal whether these emotional and cognitive changes evoked by ND were caused via direct activation of androgenic receptors (ARs) in the brain, the AR antagonist flutamide (FL) was administered intracerebroventricularly (i.c.v.). Male rats were randomly divided in four groups, one group received 15 mg/kg ND subcutaneously, once daily for 6 wk (ND group). In the second group, in addition to ND, a daily dose of 5 microg FL was injected i.c.v. also for 6 wk (ND+FL group). The third group of rats received only FL and in the control group the vehicle was injected. The ND group clearly spent more time investigating the open arms in the maze test and recognizing the juvenile during the olfactory social memory test in comparison to the control group. In the ND+FL group rats showed similar emoti...Continue Reading

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Citations

Feb 3, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joseph G Oberlander, Leslie P Henderson
Sep 16, 2009·Life Sciences·Dimitrios KouvelasMichaela M Kraus
Aug 2, 2017·Veterinary and Comparative Orthopaedics and Traumatology : V.C.O.T·Danilo R C MarquesAmanda Becker
Dec 19, 2018·Canadian Journal of Physiology and Pharmacology·Fatemeh ZareiMozhgan Veisi
Jan 23, 2021·Healthcare·Giuseppe Davide AlbanoAngelo Montana

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