Nano-bio-computing lipid nanotablet

Science Advances
Jinyoung SeoJwa-Min Nam

Abstract

Using nanoparticles as substrates for computation enables algorithmic and autonomous controls of their unique and beneficial properties. However, scalable architecture for nanoparticle-based computing systems is lacking. Here, we report a platform for constructing nanoparticle logic gates and circuits at the single-particle level on a supported lipid bilayer. Our "lipid nanotablet" platform, inspired by cellular membranes that are exploited to compartmentalize and control signaling networks, uses a lipid bilayer as a chemical circuit board and nanoparticles as computational units. On a lipid nanotablet, a single-nanoparticle logic gate senses molecules in solution as inputs and triggers particle assembly or disassembly as an output. We demonstrate a set of Boolean logic operations, fan-in/fan-out of logic gates, and a combinational logic circuit such as a multiplexer. We envisage that our approach to modularly implement nanoparticle circuits on a lipid bilayer will create new paradigms and opportunities in molecular computing, nanoparticle circuits, and systems nanoscience.

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Citations

Apr 27, 2019·Small·Jinyoung SeoJwa-Min Nam
Dec 11, 2019·Genes·Es DarleyMatthew A B Baker
Sep 15, 2020·Science Advances·Sungi KimJwa-Min Nam
Mar 25, 2021·Macromolecular Bioscience·Jiafang PiaoYuanchen Dong
Sep 26, 2019·Accounts of Chemical Research·Sungi KimJwa-Min Nam

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Methods Mentioned

BETA
light-scattering
transmission
scanning electron microscopy
size-exclusion chromatography

Software Mentioned

Assembly
NUPACK
MATLAB code
DomainDesign
MATLAB

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