Nano Carrier Drug Delivery Systems for the Treatment of Neuropsychiatric Disorders: Advantages and Limitations.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Yana ZorkinaVladimir Chekhonin

Abstract

Neuropsychiatric diseases are one of the main causes of disability, affecting millions of people. Various drugs are used for its treatment, although no effective therapy has been found yet. The blood brain barrier (BBB) significantly complicates drugs delivery to the target cells in the brain tissues. One of the problem-solving methods is the usage of nanocontainer systems. In this review we summarized the data about nanoparticles drug delivery systems and their application for the treatment of neuropsychiatric disorders. Firstly, we described and characterized types of nanocarriers: inorganic nanoparticles, polymeric and lipid nanocarriers, their advantages and disadvantages. We discussed ways to interact with nerve tissue and methods of BBB penetration. We provided a summary of nanotechnology-based pharmacotherapy of schizophrenia, bipolar disorder, depression, anxiety disorder and Alzheimer's disease, where development of nanocontainer drugs derives the most active. We described various experimental drugs for the treatment of Alzheimer's disease that include vector nanocontainers targeted on β-amyloid or tau-protein. Integrally, nanoparticles can substantially improve the drug delivery as its implication can increase BBB per...Continue Reading

References

Jun 14, 2000·Journal of Drug Targeting·Y H ChengS S Davis
Jul 18, 2002·Nature Reviews. Drug Discovery·William M Pardridge
Mar 17, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Vobalaboina Venkateswarlu, Kopparam Manjunath
Sep 27, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yoshiyuki HattoriMitsuru Hashida
Mar 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·John F Deeken, Wolfgang Löscher
Apr 11, 2007·Molecular Psychiatry·J Mill, A Petronis
Apr 18, 2007·Depression and Anxiety·Mark H PollackJack M Gorman
Dec 24, 2008·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Karthik ArumugamNayanabhirama Udupa
Jan 9, 2009·The Journal of Biological Chemistry·Linda HasadsriJulia M George
Feb 3, 2009·Biomaterials·Young-tae KimRavi V Bellamkonda
May 19, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Barnabas WilsonBhojraj Suresh
Aug 12, 2009·Neurobiology of Disease·N Joan AbbottDavid J Begley
May 28, 2010·The British Journal of Psychiatry. Supplement·John M Kane, Carlos Garcia-Ribera
Nov 17, 2009·Methods in Enzymology·Bo YuL James Lee
Feb 18, 2010·Chemical Communications : Chem Comm·Maisie J JoralemonTodd Emrick
Mar 25, 2010·ACS Nano·Eliza HutterDusica Maysinger
May 13, 2010·Chemical & Pharmaceutical Bulletin·Chun-Rong YangDa-Wei Chen
Jun 18, 2010·Biomaterials·Marco GobbiMassimo E Masserini
Jul 20, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Shrinidh A JoshiKrutika K Sawant
Oct 21, 2010·Journal of Drug Targeting·Sonal PatelKrutika Sawant
Jan 15, 2011·Drug Development and Industrial Pharmacy·N Başaran MutluAhmet Nacar
Jan 29, 2011·Angewandte Chemie·Ajay S KarakotiSudipta Seal
Mar 23, 2011·Nature Biotechnology·Lydia Alvarez-ErvitiMatthew J A Wood
Dec 1, 2009·Future Medicinal Chemistry·David D StenehjemGrant W Anderson
Jun 17, 2011·Expert Reviews in Molecular Medicine·Sagar AgarwalWilliam F Elmquist
Jul 16, 2011·Journal of Neuropathology and Experimental Neurology·Joseph F PodusloThomas M Wengenack
Oct 20, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Barbara LuppiVittorio Zecchi
Nov 29, 2011·Advanced Drug Delivery Reviews·Jeffrey J Lochhead, Robert G Thorne
Apr 10, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yechezkel Barenholz
May 9, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Mohammad FazilJaved Ali
May 23, 2012·Brain Research·C Loane, M Politis
Dec 15, 2012·Pharmacological Reports : PR·Agnieszka Z WilczewskaHalina Car
Feb 5, 2013·International Journal of Nanomedicine·Manal Fouad IsmailNeveen Abdel-Hameed Salem
Feb 16, 2013·International Journal of Pharmaceutics·Pratikkumar A PatelVandana B Patravale
Mar 19, 2013·International Journal of Biological Macromolecules·Kalpana NagpalD N Mishra
Apr 17, 2013·International Journal of Biological Macromolecules·Kalpana NagpalDinanath Mishra
May 18, 2013·International Journal of Pharmaceutics·Zhen-Zhen YangXian-Rong Qi

❮ Previous
Next ❯

Citations

Dec 31, 2020·International Journal of Molecular Sciences·Francesco TavantiMaria Cristina Menziani
Feb 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Christian J WijayaSetiyo Gunawan
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yaliang HuangJianxiu Wang
Aug 8, 2021·Nanomaterials·Alba Pensado-LópezFernando Torres Andón
Oct 4, 2021·Drug Discovery Today·Maria Camilla BergonziElisa Landucci

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy
transgenic

Related Concepts

Related Feeds

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.