Nano-emulsions prepared by the phase inversion composition method: preparation variables and scale up

Journal of Colloid and Interface Science
Isabel SolèJosé M Gutiérrez

Abstract

The aim of this work is to study, through experimental design, the effect of vessel geometry and scale-up in the properties of nano-emulsions prepared through the phase inversion composition method (PIC). Results show that a proper mixing is crucial for small droplet-sized nano-emulsions, especially when remaining free oil is found together with the key liquid crystal phase formed during the emulsification process. In these cases, mixing must be near the perfect mixed model. Proper geometries must be selected to promote a good mixture. Small addition rates V(ad) and high mixing rates omega promote the necessary mixing level. However, results indicate that, if free oil remains together with liquid crystal formed during emulsification, a too high omega could promote coalescence of oil droplets. When a cubic liquid crystal phase Pm3n is formed instead during emulsification, without free oil, coalescence is not promoted, probably due to the extremely high viscosity. For the system where Pm3n is formed during emulsification, scale-up cannot be done, as it would be expected, maintaining adimensional variables--Reynolds, Re, and adimensional time. A perfect correspondence between scales is observed when the total addition time and the...Continue Reading

References

Sep 20, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Isabel SolèJosé M Gutiérrez
Sep 19, 2008·Journal of Colloid and Interface Science·Alicia MaestroJosé M Gutiérrez

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Citations

Apr 30, 2014·Journal of Colloid and Interface Science·Jennifer Komaiko, David Julian McClements
Nov 28, 2013·International Journal of Pharmaceutics·Genoveva Morral-RuízMaría José García-Celma
Jan 10, 2014·Bulletin of Entomological Research·S SugumarN Chandrasekaran
Apr 6, 2012·Annual Review of Physical Chemistry·Michael M Fryd, Thomas G Mason
Oct 12, 2013·Journal of Pharmaceutical Sciences·Sanela M ĐorđevićSnežana D Savić
Jul 15, 2015·International Journal of Cosmetic Science·M N YukuyamaN A Bou-Chacra
Aug 16, 2011·Micron : the International Research and Review Journal for Microscopy·Victoria KlangFerdinand Hofer
Feb 16, 2010·Journal of Colloid and Interface Science·Mabel CapdevilaJosé M Gutiérrez
Jan 31, 2015·Advances in Colloid and Interface Science·A PerazzoS Guido
Feb 13, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Hanhee ParkJin Woong Kim
Feb 24, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Genoveva Morral-RuízMaría José García-Celma
Mar 19, 2020·Current Pharmaceutical Design·Md A BarkatFarhan J Ahmad
Jan 24, 2017·Journal of Surfactants and Detergents·Małgorzata A MiastkowskaMichał Zielina
Dec 25, 2019·Journal of Colloid and Interface Science·Li-Chiun ChengPatrick S Doyle
Feb 2, 2013·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·I HoffmannM Gradzielski
Jun 19, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Barbara Kupikowska-Stobba, Mirosław Kasprzak
Sep 19, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Lijie YuDejun Sun
Feb 4, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Manal HessienEric Prouzet
Nov 19, 2018·International Journal of Pharmaceutics·Letícia StreckArnóbio A da Silva-Júnior

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