Nano-enabled bioanalytical approaches to ultrasensitive detection of low abundance single nucleotide polymorphisms

The Analyst
Lorico D S LapitanDejian Zhou

Abstract

Single nucleotide polymorphisms (SNPs) constitute the most common types of genetic variations in the human genome. A number of SNPs have been linked to the development of life threatening diseases including cancer, cardiovascular diseases and neurodegenerative diseases. The ability for ultrasensitive and accurate detection of low abundant disease-related SNPs in bodily fluids (e.g. blood, serum, etc.) holds a significant value in the development of non-invasive future biodiagnostic tools. Over the past two decades, nanomaterials have been utilized in a myriad of biosensing applications due to their ability of detecting extremely low quantities of biologically important biomarkers with high sensitivity and accuracy. Of particular interest is the application of such technologies in the detection of SNPs. The use of various nanomaterials, coupled with different powerful signal amplification strategies, has paved the way for a new generation of ultrasensitive SNP biodiagnostic assays. Over the past few years, several ultrasensitive SNP biosensors capable of detecting specific targets down to the ultra-low regimes (ca. aM and below) and therefore holding great promises for early clinical diagnosis of diseases have been developed. Th...Continue Reading

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Citations

Oct 21, 2016·Journal of Colloid and Interface Science·Antonino RapisardaGiovanni Marletta
Nov 26, 2016·Chemical Communications : Chem Comm·A J CoxD M Kolpashchikov
Apr 20, 2017·Chembiochem : a European Journal of Chemical Biology·Maryam Imani NejadKent S Gates
Apr 23, 2020·Journal of Nanobiotechnology·Congli TangNongyue He
Aug 23, 2017·Analytical Chemistry·Sahar Sadat MahshidShana O Kelley

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Methods Mentioned

BETA
PCR
biosensing
FRET
surface enhanced Raman spectroscopy
electrophoresis
circular dichroism
DNA assay
surface plasmon resonance
ELISA
biosensors

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