Nano-Enabled COVID-19 Vaccines: Meeting the Challenges of Durable Antibody Plus Cellular Immunity and Immune Escape.

ACS Nano
André E Nel, Jeff F Miller

Abstract

At the time of preparing this Perspective, large-scale vaccination for COVID-19 is in progress, aiming to bring the pandemic under control through vaccine-induced herd immunity. Not only does this vaccination effort represent an unprecedented scientific and technological breakthrough, moving us from the rapid analysis of viral genomes to design, manufacture, clinical trial testing, and use authorization within the time frame of less than a year, but it also highlights rapid progress in the implementation of nanotechnology to assist vaccine development. These advances enable us to deliver nucleic acid and conformation-stabilized subunit vaccines to regional lymph nodes, with the ability to trigger effective humoral and cellular immunity that prevents viral infection or controls disease severity. In addition to a brief description of the design features of unique cationic lipid and virus-mimicking nanoparticles for accomplishing spike protein delivery and presentation by the cognate immune system, we also discuss the importance of adjuvancy and design features to promote cooperative B- and T-cell interactions in lymph node germinal centers, including the use of epitope-based vaccines. Although current vaccine efforts have demonst...Continue Reading

References

Apr 27, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Inge S ZuhornDick Hoekstra
Aug 24, 2007·Advances in Experimental Medicine and Biology·Dhruba J BharaliYasmin Thanavala
Sep 18, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Katalin KarikóDrew Weissman
Feb 10, 2009·Nature Reviews. Microbiology·Lanying DuShibo Jiang
Jan 19, 2010·Nature Biotechnology·Sean C SempleMichael J Hope
Jul 9, 2011·Nature Immunology·Stephen L Nutt, David M Tarlinton
Jan 10, 2013·Annual Review of Immunology·Janice S BlumPeter Cresswell
Mar 7, 2013·Bioconjugate Chemistry·Defu ZhiDefeng Zhao
Sep 23, 2014·Nature Reviews. Drug Discovery·Ugur SahinÖzlem Türeci
Oct 11, 2014·Nucleic Acids Research·Randi VitaBjoern Peters
Jan 27, 2015·Advances in Genetics·Luis A BritoAndrew J Geall
Oct 13, 2015·Advanced Drug Delivery Reviews·Jung Soo SukLaura M Ensign
Dec 22, 2015·Nature Reviews. Immunology·Scott N Mueller, Laura K Mackay
Jan 28, 2016·Genome Medicine·Benjamin Schubert, Oliver Kohlbacher
Mar 5, 2016·Nature·Robert N KirchdoerferAndrew B Ward
Mar 16, 2016·Seminars in Immunology·Dirk H BuschStanley R Riddell
Apr 15, 2016·Therapeutic Delivery·Andreas M ReichmuthDaniel Blankschtein
Jun 28, 2016·Nature Reviews. Microbiology·Emmie de WitVincent J Munster
Oct 9, 2016·Methods in Molecular Biology·John D Campbell
Dec 18, 2016·Methods in Molecular Biology·Norbert Pardi, Drew Weissman
Apr 17, 2017·Molecular Therapy : the Journal of the American Society of Gene Therapy·Pieter R Cullis, Michael J Hope
Jul 14, 2017·Expert Review of Vaccines·Carlo IavaroneJeffrey B Ulmer
Aug 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Jesper PallesenJason S McLellan
Jan 13, 2018·Nature Reviews. Drug Discovery·Norbert PardiDrew Weissman
Mar 17, 2018·Analytical and Bioanalytical Chemistry·Lorenzo BarontiKatja Petzold
Apr 5, 2018·Vaccines·Francesco Berlanda Scorza, Norbert Pardi
May 10, 2018·The Journal of Experimental Medicine·Norbert PardiDrew Weissman
May 24, 2018·Bioinformatics·James HadfieldRichard A Neher
Oct 20, 2018·Frontiers in Immunology·Rashmirekha PatiAvinash Sonawane
Jan 30, 2019·Annual Review of Medicine·Barney S GrahamJason S McLellan
Mar 9, 2019·Molecular Therapy : the Journal of the American Society of Gene Therapy·Piotr S KowalskiDaniel G Anderson
Apr 30, 2019·Vaccine·Catherine CohetBruce L Innis

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Citations

May 5, 2021·Expert Opinion on Drug Delivery·Miguel Pereira-SilvaAna Cláudia Paiva-Santos
Jun 5, 2021·Peptides·Catherine H ScheinJurgen Schmidt

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Software Mentioned

AdaptVac
CELLECTRA
COVAXX
Novavax
EpiVacCorona
IEDB
Mediphage

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