Nano-enabled SERS reporting photosensitizers

Theranostics
Arash FarhadiGang Zheng

Abstract

To impart effective cellular damage via photodynamic therapy (PDT), it is vital to deliver the appropriate light dose and photosensitizer concentration, and to monitor the PDT dose delivered at the site of interest. In vivo monitoring of photosensitizers has in large part relied on their fluorescence emission. Palladium-containing photosensitizers have shown promising clinical results by demonstrating near full conversion of light to PDT activity at the cost of having undetectable fluorescence. We demonstrate that, through the coupling of plasmonic nanoparticles with palladium-photosensitizers, surface-enhanced Raman scattering (SERS) provides both reporting and monitoring capability to otherwise quiescent molecules. Nano-enabled SERS reporting of photosensitizers allows for the decoupling of the therapeutic and imaging mechanisms so that both phenomena can be optimized independently. Most importantly, the design enables the use of the same laser wavelength to stimulate both the PDT and imaging features, opening the potential for real-time dosimetry of photosensitizer concentration and PDT dose delivery by SERS monitoring.

Citations

Sep 24, 2015·International Journal of Biological Macromolecules·Shweta AgarwalRanjana Mehrotra
Aug 16, 2016·IEEE Journal of Selected Topics in Quantum Electronics : a Publication of the IEEE Lasers and Electro-optics Society·Yu WangJonathan T C Liu
Jun 16, 2015·Frontiers in Chemistry·Dayane B Tada, Mauricio S Baptista
Dec 19, 2018·Coordination Chemistry Reviews·Shuai ShaoJonathan F Lovell
Jun 27, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·F LuciaU Schick
Sep 13, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Jason Haber, Konstantin Sokolov
Dec 1, 2017·Bioconjugate Chemistry·Domenico CassanoValerio Voliani
Oct 29, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Maria C GomesJoão P C Tomé

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Methods Mentioned

BETA
using
dynamic light scattering
fluorescence microscopy
fluorescence imaging

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