Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB

Journal of Controlled Release : Official Journal of the Controlled Release Society
Guobao WeiPeter X Ma

Abstract

The localized and temporally controlled delivery of growth factors is key to achieving optimal clinical efficacy. In sophisticated tissue engineering strategies, the biodegradable scaffold is preferred to serve as both a three-dimensional (3-D) substrate and a growth factor delivery vehicle to promote cellular activity and enhance tissue neogenesis. This study presents a novel approach to fabricate tissue engineering scaffolds capable of controlled growth factor delivery whereby growth factor containing microspheres were incorporated into 3-D scaffolds with good mechanical properties, well-interconnected macroporous and nano-fibrous structures. The microspheres were uniformly distributed throughout the nano-fibrous scaffold and their incorporation did not interfere the macro-, micro-, and nanostructures of the scaffold. The release kinetics of platelet-derived growth factor-BB (PDGF-BB) from microspheres and scaffolds was investigated using poly(lactic-co-glycolic acid) (PLGA50) microspheres with different molecular weights (6.5 and 64kDa, respectively) and microsphere-incorporated poly(l-lactic acid) (PLLA) nano-fibrous scaffolds. Incorporation of microspheres into scaffolds significantly reduced the initial burst release. Sus...Continue Reading

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Citations

Aug 12, 2009·Journal of Materials Science. Materials in Medicine·G J S DawesJ Duszczyk
Nov 19, 2011·Journal of Materials Science. Materials in Medicine·Gongwen TangMin Wang
Jan 15, 2011·Pharmaceutical Research·Jiang Hu, Peter X Ma
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Feb 21, 2016·Colloids and Surfaces. B, Biointerfaces·Hai WangZhihong Wu
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Aug 21, 2015·Drug Development and Industrial Pharmacy·Mirhamed HajimiriRassoul Dinarvand
Jan 19, 2013·Expert Opinion on Biological Therapy·Zhanpeng ZhangPeter X Ma
Jun 8, 2011·Expert Opinion on Drug Delivery·Brian G Amsden
Jan 12, 2016·Colloids and Surfaces. B, Biointerfaces·Nermin KelogluJérôme Sohier
Dec 3, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Salwa SulimanKamal Mustafa
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Jun 3, 2015·Advanced Drug Delivery Reviews·Haibo QuPaul Ducheyne
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May 19, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jianjun GuanWilliam R Wagner

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