Nano-mechanical model of endothelial dysfunction for AFM-based diagnostics at the cellular level

Pharmacological Reports : PR
Marek SzymonskiKatarzyna E Malek-Zietek

Abstract

A review of recent experimental investigations on the nanomechanical response of individual endothelial cells to inflammation caused by environmental agents and selected chemical compounds is presented. We focus on the results obtained by means of the force spectroscopy using the tip of an atomic force microscope as an imaging and nanoindentation spectroscopic probe. The findings presented in this review allow validating the nanoindentation method as a tool for quantitative cell elasticity probing and thereby allow proposing a nanomechanical model of endothelial dysfunction that could be practically used for drug efficacy and toxicity profiling in the endothelium at the subcellular level.

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Citations

Sep 1, 2015·Pharmacological Reports : PR·Stefan Chlopicki
Apr 5, 2017·Journal of Molecular Recognition : JMR·Katarzyna E Malek-ZietekMarek Szymonski
Oct 1, 2019·Traffic·Bartlomiej ZapotocznyMarek Szymonski
Nov 13, 2017·Pharmacological Reports : PR·Agnieszka M KolodziejczykMarek Szymonski
May 20, 2020·Biophysics Reviews·Bartlomiej ZapotocznyMarek Szymonski
Jan 13, 2018·Scientific Reports·Aleksei Kabedev, Vladimir Lobaskin
May 12, 2018·Journal of Molecular Recognition : JMR·Agnieszka KolodziejczykBogdan Walkowiak
Dec 2, 2018·Frontiers in Physiology·Francesco BasoliAlberto Rainer
Oct 22, 2019·Biochimica Et Biophysica Acta. Biomembranes·Marta Targosz-KoreckaPatrycja Dynarowicz-Latka
Aug 24, 2017·Seminars in Cell & Developmental Biology·S KasasG Dietler

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