Nano-Medicines a Hope for Chagas Disease!

Frontiers in Molecular Biosciences
Satabdi Datta Choudhury

Abstract

Chagas disease, is a vector-mediated tropical disease whose causative agent is a parasitic protozoan named Trypanosoma cruzi. It is a very severe health issue in South America and Mexico infecting millions of people every year. Protozoan T. cruzi gets transmitted to human through Triatominae, a subfamily of the Reduviidae, and do not have any effective treatment or preventative available. The lack of economic gains from this tropical parasitic infection, has always been the reason behind its negligence by researchers and drug manufacturers for many decades. Hence there is an enormous requirement for more efficient and novel strategies to reduce the fatality associated with these diseases. Even, available diagnosis protocols are outdated and inefficient and there is an urgent need for rapid high throughput diagnostics as well as management protocol. The current advancement of nanotechnology in the field of healthcare has generated hope for better management of many tropical diseases including Chagas disease. Nanoparticulate systems for drug delivery like poloxamer coated nanosuspension of benzimidazole have shown promising results in reducing toxicity, elevating efficacy and bioavailability of the active compound against the pat...Continue Reading

References

Oct 1, 1990·Biomaterials·R H MüllerP Couvreur
Apr 1, 1985·British Medical Bulletin·W E Gutteridge
Jun 1, 1987·Life Sciences·E YoshiharaT Nakae
Oct 1, 1994·The Journal of Experimental Medicine·S N MorenoR Docampo
Jul 1, 1994·Molecular and Biochemical Parasitology·M A YakubuF Kierszenbaum
May 15, 1996·Biochemical and Biophysical Research Communications·S E WilkowskyE L Isola
Oct 24, 1997·International Archives of Allergy and Immunology·Z Brener, R T Gazzinelli
May 15, 1998·The Journal of Pharmacy and Pharmacology·G Gonzalez-MartinA Osuna
Jan 19, 2000·Parasitology Today·G M KrautzA U Krettli
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·R M VabulasH Wagner
Mar 8, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·G González-MartínA Osuna
Apr 29, 2000·Pharmaceutical Science & Technology Today·G M Barratt
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·R H MüllerS Gohla
Apr 20, 2001·Advanced Drug Delivery Reviews·W Mehnert, K Mäder
Jul 4, 2001·The Journal of Biological Chemistry·A MontalvettiR Docampo
Aug 4, 2001·The American Journal of Pathology·M B SoaresR Ribeiro-dos-Santos
Nov 29, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Manoel O C RochaMauro M Teixeira
Oct 29, 2003·Trends in Parasitology·Julio A Urbina, Roberto Docampo
Apr 28, 2004·Advanced Drug Delivery Reviews·S A WissingR H Müller
Jan 18, 2005·Journal of Cell Science·Keith R Matthews
Feb 8, 2005·The Journal of Clinical Investigation·Daniel E SpeiserPedro Romero
Apr 12, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Maria Jose MorillaEder Lilia Romero
Jul 16, 2005·Memórias do Instituto Oswaldo Cruz·Maria Jose MorillaEder Lilia Romero
Sep 10, 2005·Trends in Parasitology·Simon L CroftJulio A Urbina
Nov 25, 2005·Current Drug Delivery·Dipak K Sarker
Dec 13, 2005·Anais Da Academia Brasileira De Ciências·Michele A ZacksNisha Garg
Jan 25, 2006·International Immunology·María Cecilia AlbaredaMiriam Postan
Apr 22, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Juan Diego MayaAntonio Morello
Jul 22, 2006·Analytical Chemistry·Fernando PatolskyCharles M Lieber
Oct 20, 2006·International Journal of Pharmaceutics·D G LendemansT Rades
Jan 26, 2007·Experimental Parasitology·C R AlvesM S Gonzalez
Feb 13, 2007·International Journal of Pharmaceutics·Sávia Caldeira de AraújoMônica Cristina de Oliveira

❮ Previous
Next ❯

Related Concepts

Related Papers

Tijdschrift voor ziekenverpleging
The New England Journal of Medicine
Caryn Bern
The New England Journal of Medicine
Reinaldo B BestettiCarolina B A Restini
Revista brasileira de medicina
A DE PAULA
International Journal of Dermatology
W Abramovits-AckermanJ Torres
© 2021 Meta ULC. All rights reserved