Nano-microbicides: challenges in drug delivery, patient ethics and intellectual property in the war against HIV/AIDS

Advanced Drug Delivery Reviews
Lisa C du ToitYahya E Choonara

Abstract

As we continue to be embroiled in the global battle against the human immunodeficiency virus (HIV), there has been an ongoing evolution in the understanding of the molecular mode of sexual transmission of HIV. This has gone hand-in-hand with a paradigm shift and research focus on the development of microbicides - compounds designed for vaginal (and possibly rectal) administration that are envisaged to put safe, affordable and accessible protection into the hands of women. However, an effective microbicide is not yet available; innovative approaches for the design of topical vaginal microbicides are urgently needed. The potential of the advancing field of nanomedicine has been earmarked in the increasing efforts to address the major health problems of the developing world. In this review, advances in the design of innovative microbicide nanocarriers and nano-enabled microbicides, henceforth referred to as 'nano-microbicides', are presented; elaborating on nanotechnology's role in the antiviral arena. The role of nanotechnology in the antiviral arena and the unique issues facing the generation of intellectual property relating to nano-microbicides in the ongoing global 'tug-of-war' of 'patients versus patents' are also explicated.

References

Apr 1, 1990·American Journal of Public Health·Z A Stein
Aug 26, 1998·Sexually Transmitted Diseases·S L RosenthalL R Stanberry
Jul 30, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Z PavelićI Jalsenjak
Aug 19, 2000·Antiviral Chemistry & Chemotherapy·M Lüscher-Mattli
Aug 22, 2000·Antimicrobial Agents and Chemotherapy·N BourneD I Bernstein
Feb 19, 2002·Chemical Reviews·A. W. BosmanE. W. Meijer
May 2, 2002·Nature Medicine·Robin J Shattock, Robert W Doms
Dec 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·J GorelikY Korchev
Jan 4, 2003·Science·Rebecca Spieler Trager
Apr 4, 2003·International Journal of Pharmaceutics·Jaspreet Kaur VasirSanjay Garg
Apr 19, 2003·Science·M Potts, R V Short
Dec 4, 2003·Bioorganic & Medicinal Chemistry Letters·Susanna BosiMaurizio Prato
Mar 26, 2004·Nature Reviews. Microbiology·Robin J Shattock, John P Moore
Jun 26, 2004·Science·Paul M CoplanZeda F Rosenberg
Aug 4, 2004·Contraception·David M PhillipsRobin A Maguire
Jan 22, 2005·Journal of Nanobiotechnology·Gilles K KouassiGregory McCarty
Apr 27, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sharon L HillierFulvia Veronese
Jun 28, 2005·Bioorganic & Medicinal Chemistry Letters·Silvia MarchesanMaurizio Prato
Oct 26, 2005·Chemistry & Biology·George P TegosMichael R Hamblin
Feb 4, 2006·Science·Andre NelNing Li
Feb 18, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ken DonaldsonAndrew Alexander
Nov 23, 2006·Advanced Drug Delivery Reviews·Lara LacerdaKostas Kostarelos
Jan 27, 2007·Current Opinion in Biotechnology·Shelton D CaruthersGregory M Lanza
Aug 4, 1972·Science·P W Anderson
Nov 21, 2007·AIDS·Janneke Hhm van de Wijgert, Robin J Shattock
Mar 11, 2008·Nanomedicine : Nanotechnology, Biology, and Medicine·Igor LinkovLisa M Corey
May 14, 2008·Journal of the American Chemical Society·Mary-Catherine BowmanChristian Melander
Jul 10, 2008·Nature Biotechnology·Vivien Marx
Jul 17, 2008·AIDS Research and Human Retroviruses·Wang TaoDean Hamer

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Citations

Jun 4, 2013·Biomaterials·Abhijit A Date, Christopher J Destache
May 21, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Željka Vanić, Nataša Škalko-Basnet
Oct 20, 2010·International Journal of Nanomedicine·Rama Mallipeddi, Lisa Cencia Rohan
Apr 15, 2014·Organic & Biomolecular Chemistry·Marta GalánRafael Gómez
Oct 18, 2014·Cellular and Molecular Life Sciences : CMLS·Jill M Steinbach
Feb 22, 2012·Expert Review of Anti-infective Therapy·Bruno PozzettoThomas Bourlet
Jun 25, 2014·Expert Opinion on Drug Delivery·Tin Wui WongMichael John Rathbone
Feb 2, 2016·Advanced Drug Delivery Reviews·José das NevesBruno Sarmento
May 17, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Laura M EnsignJustin Hanes
Mar 26, 2011·Journal of Pharmaceutical Sciences·Dima AlukdaBi-Botti C Youan
Aug 25, 2011·Biomaterials·Nikita K MalaviaDaniel S Kohane
Nov 17, 2009·Advanced Drug Delivery Reviews·Alejandro Sosnik, Mansoor Amiji
Nov 1, 2015·Biochemical and Biophysical Research Communications·Esther H ChangDong Soo Lee
May 20, 2014·Advances in Colloid and Interface Science·Ignác Capek
Apr 21, 2011·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·José das NevesBruno Sarmento
Jun 21, 2011·Advances in Colloid and Interface Science·Panagiotis DallasRadek Zboril
Apr 11, 2015·Advanced Drug Delivery Reviews·Sophia G Antimisiaris, Spyridon Mourtas
Jan 1, 2015·Advanced Drug Delivery Reviews·José das NevesBruno Sarmento
Jul 9, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Tao ZhangBi-Botti C Youan
Jun 7, 2014·Journal of Laboratory Automation·Nathaniel TsaiDean Ho
Jun 8, 2017·Journal of Applied Toxicology : JAT·Hong SuMin Ding
Feb 16, 2019·Recent Patents on Drug Delivery & Formulation·Zeenat Iqbal, Fahima Dilnawaz
Sep 13, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Beatriz RasinesRafael Gómez

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