Nano-photosensitizer based on layered double hydroxide and isophthalic acid for singlet oxygenation and photodynamic therapy

Nature Communications
Rui GaoMin Wei

Abstract

Singlet oxygen has won a great deal of attention to catalysis and biological studies due to its strong oxidizing properties. However, the photosensitizers which require for the generation of singlet oxygen remain inadequate because of their lack of long-wavelength absorption, weak hydrophilicity, and poor biocompatibility. Here, we develop near-infrared laser activated supramolecular photosensitizers (isophthalic acid/layered double hydroxide nanohybrids) for efficient two-photon photodynamic therapy. The singlet oxygen quantum yield of nanohybrid is up to 0.74. Critically, in vitro tests verify the superior anti-cancer properties of nanohybrid with an IC50 determine to be 0.153 μg mL-1. The nanohybrids take advantage of the superior tissue penetration of 808 nm laser irradiation and exhibit a dramatically strong ability to ablate tumors in vivo, with extremely low toxicity. This work provides the proof of concept that ultralong-lived triplet excitons can function as two-photon-activated photosensitizers for an effective singlet oxygen generation.

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Citations

Jul 30, 2019·Advanced Materials·Liang ChengZhuang Liu
Oct 5, 2019·Nanomaterials·Wenji Jin, Dae-Hwan Park
Jan 30, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Liang YanMin Wei
Jan 30, 2020·Nanoscale·Jinyi Zhang, Juewen Liu
Oct 28, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Xuan MeiMin Wei
Mar 4, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhenzhen LiHong Bi
May 7, 2020·Frontiers in Chemistry·Zhengdi WangMin Wei
Apr 2, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Linhua LiaoGaorong Han
Aug 1, 2020·Beilstein Journal of Organic Chemistry·Dominik GöbelBoris J Nachtsheim
Dec 12, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhengdi WangRuizheng Liang
Nov 5, 2020·Biotechnology Reports·Lorena Cristina Nunes de AlmeidaMoisés Hamoy
Feb 2, 2021·Methods and Applications in Fluorescence·Xiao-Hui WangHong-Xin Zhang
Feb 25, 2021·Research : a Science Partner Journal·Ye TaoWei Huang
Mar 11, 2021·Chemical Society Reviews·Rui GaoDongpeng Yan
Apr 23, 2021·Macromolecular Bioscience·Liwen FuChuanglong He
Jul 3, 2021·International Journal of Molecular Sciences·Banendu Sunder DashJyh-Ping Chen

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Methods Mentioned

BETA
ESR
AFM
dynamic light scattering
fluorescence scanning microscopy
flow cytometry
fluorescence imaging
atomic force microscopy

Software Mentioned

PKSolver

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