Nano-scale characterization of nano-hydroxyapatite incorporated chitosan particles for bone repair

Colloids and Surfaces. B, Biointerfaces
Bipin GaihreA Champa Jayasuriya

Abstract

In this study, injectable porous spherical particles were fabricated using chitosan (CS) biopolymer, sodium tripolyphosphate (TPP), and nano-hydroxyapatite (nHA). TPP was primarily used as an ionic crosslinker to crosslink 2% (w/v) CS droplets. 2% (w/v) nHA was used to prepare nHA incorporated particles. The surface morphological properties and nanomechanical properties such as topography, deformation, adhesion, and dissipation of CS particles with and without nHA were studied using contact mode and peakforce quantitative nanomechanical property mapping mode in atomic force microscopy. The nHA spots have higher density than CS which leads to higher forces acting on the probe tip and higher energy dissipation to lift the tip from nHA areas. The cumulative release data showed that about 87% of total BMP-2 encapsulated within the particles was released by third week of experiment period. Degradation study was conducted to understand how the particles degradation occurs in the presence of phosphate buffered saline with continues shaking in an incubator at 37° C. In addition, BMP-2 release from the 2% nHA/CS particles was studied over a three weeks period and found that BMP-2 release was governed by the simple diffusion rather than ...Continue Reading

References

Oct 8, 2003·Current Pharmaceutical Biotechnology·Yoshinori KatoYoshiharu Machida
Apr 21, 2004·Annals of Biomedical Engineering·Nichole R MercierLawrence J Bonassar
Jul 16, 2005·Journal of Microencapsulation·K G H Desai, H J Park
Feb 25, 2006·International Journal of Pharmaceutics·Anil K AnalCarmen Remuñán-López
Sep 22, 2007·Biotechnology Advances·In-Yong KimChong-Su Cho
Dec 20, 2007·Oral and Maxillofacial Surgery Clinics of North America·Ugo RipamontiCarlo Ferretti
Jan 6, 2009·Acta Biomaterialia·W W Thein-Han, R D K Misra
Sep 26, 2009·Biomedical Materials·A Champa Jayasuriya, Archana Bhat
Oct 22, 2009·International Orthopaedics·Ippokratis PountosPeter V Giannoudis
Nov 17, 2009·Biotechnology Advances·R JayakumarH Tamura
Feb 13, 2013·Journal of Biomedical Materials Research. Part a·Michael B DreifkeAmbalangodage C Jayasuriya
May 1, 2013·Physical Chemistry Chemical Physics : PCCP·J Landoulsi, V Dupres
Jul 27, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Venkata P Mantripragada, Ambalangodage C Jayasuriya
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Suren P UswattaAmbalangodage C Jayasuriya
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Bipin Gaihre, Ambalangodage C Jayasuriya
Feb 18, 2017·Journal of Functional Biomaterials·Marica MarreseLuigi Ambrosio
Apr 11, 2017·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Juan WuQiang Zeng
Nov 22, 2017·Journal of Functional Biomaterials·Bipin GaihreAmbalangodage C Jayasuriya
Nov 22, 2017·Journal of Biomaterials Applications·Bipin GaihreAmbalangodage C Jayasuriya

❮ Previous
Next ❯

Citations

Nov 30, 2019·Nanomedicine·Michael J HillMorteza Mahmoudi
Sep 9, 2019·ACS Biomaterials Science & Engineering·Bipin GaihreAmbalangodage C Jayasuriya

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Materials Science & Engineering. C, Materials for Biological Applications
Suren P UswattaA Champa Jayasuriya
Shanghai kou qiang yi xue = Shanghai journal of stomatology
Feng LiuXiao-long Zang
Journal of Biomedical Science and Engineering
A Champa Jayasuriya, Kristalyn J Mauch
© 2022 Meta ULC. All rights reserved