PMID: 15338587Sep 2, 2004Paper

Nano-scaled hydroxyapatite/polymer composite I. Coating of sintered hydroxyapatite particles on poly(gamma-methacryloxypropyl trimethoxysilane)grafted silk fibroin fibers through chemical bonding

Journal of Materials Science. Materials in Medicine
Tsutomu FuruzonoJ Tanaka

Abstract

The inorganic-organic composite consisting of nano-scaled hydroxyapatite (HAp) and silk fibroin (SF) fibers was prepared through covalent linkage to develop a novel biomaterial for a soft-tissue-compatible material. The preparation of the composite was conducted through the three-step procedure consisting of chemical modification using 2-methacryloxyethyl isocyanate (MOI) monomer to introduce vinyl groups on SF, poly(gamma-methacryloxypropyl trimethoxysilane) (MPTS) graft-polymerization on SF, and coupling process between the surface of polyMPTS-grafted SF and HAp nano-particles. The amount of the graft-polymerization of polyMPTS through vinyl groups was well controlled by the reaction time. The nano-crystals were subsequently coated on the grafted fibers by heating at 120 degrees C for 2 h in a vacuum. The crystalline structure of the SF substrate did not change in the procedure. In the SEM observation of the composite surface, it was found that the bonded nano-crystals were separated and partially aggregated with several crystals attached on the SF fiber surface. The HAp particles adhered more strongly on the SF surface with separation or aggregation of several crystals than on the surface of the original SF after ultrasonic ...Continue Reading

Citations

Aug 13, 2011·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Hiroshi YanagidaTsutomu Furuzono
Jan 26, 2008·Journal of Materials Science. Materials in Medicine·Shu-Hua TengHyoun-Ee Kim
Oct 8, 2008·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Vladimir G BogushMikhail P Kirpichnikov
Mar 5, 2010·Molekuliarnaia biologiia·O S SokolovM P Kirpichnikov
Jan 21, 2010·International Journal of Molecular Sciences·Fukumi HiragamiYoshio Kano
Jul 27, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Yuko OmoriNaoyuki Matsumoto
Aug 12, 2009·Journal of Bioscience and Bioengineering·Hiroshi YanagidaKazuo Takakuda
Nov 6, 2008·Journal of Biomedical Materials Research. Part a·Toshimitsu TanakaKanichi Seto
Dec 19, 2007·Journal of Biomedical Materials Research. Part a·Rui YohTaiji Sohmura
Nov 13, 2007·Journal of Biomedical Materials Research. Part a·Masahiro OkadaTsutomu Furuzono
May 28, 2016·Nanomedicine·Zhanpeng ZhangPeter X Ma
Dec 3, 2014·Progress in Neurobiology·Amy M HopkinsDavid L Kaplan
Jun 9, 2006·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Tsutomu FuruzonoKunio Miyatake
Apr 3, 2008·Journal of Tissue Engineering and Regenerative Medicine·Ana C MacIntoshPaul V Hatton
Feb 22, 2017·The Open Orthopaedics Journal·Brian Lee Perkins, Naghmeh Naderi
Sep 4, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Tsutomu FuruzonoEnyu Imai
Dec 28, 2012·Science and Technology of Advanced Materials·Masahiro Okada, Tsutomu Furuzono
Jan 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hiromitsu SogawaKeiji Numata
Jan 1, 2007·Progress in Polymer Science·Charu Vepari, David L Kaplan

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