Nano titanium dioxide photocatalytic protein tyrosine nitration: a potential hazard of TiO2 on skin

Biochemical and Biophysical Research Communications
Naihao LuZhong-Hong Gao

Abstract

Protein tyrosine nitration is a prevalent post-translational modification which occurs as a result of oxidative and nitrative stress, it may be directly involved in the onset and/or progression of diseases. Considering the existence of nano titanium dioxide (TiO(2)) in environment and sunscreen products along with the high content of nitrite in sweat, the UV-exposed skin may be a significant target for the photosensitized damage. In this paper, tyrosine nitration of bovine serum albumin (BSA) was initiated in the UV-irradiated reaction mixture containing 0.2-3.0mg/ml of three commercially nano TiO(2) products and 0.25-1.0mM NO2-. It was found that anatase TiO(2) and Degussa P25 TiO(2) showed prominent photocatalytic activity on promoting the formation of protein tyrosine nitration, and the optimum condition for the reaction was around physiological pH. Meanwhile, the photocatalytic effect of rutile on protein tyrosine nitration was subtle. The potential physiological significance of nano TiO(2)-photocatalytic protein nitration was also demonstrated in mouse skin homogenate. Although the relationship between photocatalytic protein tyrosine nitration and chronic cutaneous diseases needs further study, the toxicity of nano TiO(2) ...Continue Reading

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Citations

Apr 25, 2009·Environmental Science and Pollution Research International·Zhen XuHong-Wen Gao
Aug 1, 2013·International Journal of Nanomedicine·Kui LiuJinshun Zhao
Aug 31, 2012·Radiology and Oncology·Matej SkocajSasa Novak
Dec 29, 2012·Journal of Hazardous Materials·Min TuZhonghong Gao
Mar 16, 2012·Journal of Photochemistry and Photobiology. B, Biology·Shazia TanvirSylviane Pulvin
Nov 29, 2011·Journal of Hazardous Materials·Ruinan ZhangBing Yan
Mar 22, 2014·Chemical Society Reviews·Yi ZhangBing Yan
Jan 1, 2015·Beilstein Journal of Nanotechnology·Annika VogtJürgen Lademann
May 28, 2019·Environmental Science and Pollution Research International·Eman Ahmed Alaa El-DinDalia Abdallah El-Shafei
Mar 27, 2013·Experimental Dermatology·Koji AdachiOsamu Yamamoto
Mar 2, 2013·Physical Chemistry Chemical Physics : PCCP·Zi Fei YinYong Hua Su
Jun 18, 2011·Journal of the American Chemical Society·Saji GeorgeLutz Mädler

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