Nano-Vesicles are a Potential Tool to Monitor Therapeutic Efficacy of Carbon Ion Radiotherapy in Prostate Cancer

Journal of Biomedical Nanotechnology
Qi YuShen Fu

Abstract

Exosomes are nano-vesicles that contribute to the effectiveness of many treatments. The aim of this study was to identify profiles of microRNA (miRNA) contained in serum exosomes that are differentially regulated in patients with prostate cancer undergoing carbon ion radiotherapy (CIRT). RNA was extracted from serum exosomes of eight patients with localized prostate cancer before and after CIRT, and miRNA was analyzed by the next generation sequencing. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that the major signaling pathways associated with the proliferation of prostate cancer cells, such as MAPK, PI3K-AKT, mTOR, and AMPK may be implicated in the mechanism of CIRT action. Notably, 57 miRNAs present in serum exosomes were significantly altered after application of CIRT. A high pre-CIRT expression level of specific miRNAs (miR-493-5p, miR-323a-3p, miR-411-5p, miR-494-3p, miR-379-5p, miR-654-3p, miR-409-3p, miR-543, and miR-200c-3p) predicted therapeutic benefit of CIRT (P < 0.05). Post-CIRT expression of miR-654-3p and miR-379-5p was also associated with CIRT efficacy (P < 0.05). These results suggest that the anti-prostate cancer mechanisms elicited by CIRT at the molecular level may involve exosom...Continue Reading

Citations

Nov 9, 2019·International Journal of Molecular Sciences·Tünde SzatmáriKatalin Lumniczky
Jan 16, 2020·Cells·Ines StevicFranz Lennard Ricklefs
Jul 9, 2020·International Journal of Molecular Sciences·Camille HuartAnne-Catherine Wéra
Sep 5, 2020·OncoTargets and Therapy·Jiang-Tao PuTian-Yang Dai
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Nov 11, 2019·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·M Helena VasconcelosAija Linē
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May 22, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Michael P RimmerRod T Mitchell
Jun 26, 2021·The World Journal of Men's Health·Jiancheng PanQiliang Cai
Aug 14, 2021·Seminars in Cancer Biology·V Vlaeminck-Guillem
Aug 21, 2021·Frontiers in Oncology·Sílvia SoaresRúben Fernandes

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