Nanoantibiotics: A Novel Rational Approach to Antibiotic Resistant Infections

Current Drug Metabolism
Ayse Basak Engin, Atilla Engin

Abstract

The main drawbacks for using conventional antimicrobial agents are the development of multiple drug resistance due to the use of high concentrations of antibiotics for extended periods. This vicious cycle often generates complications of persistent infections, and intolerable antibiotic toxicity. The problem is that while all new discovered antimicrobials are effective and promising, they remain as only short-term solutions to the overall challenge of drug-resistant bacteria. Recently, nanoantibiotics (nAbts) have been of tremendous interest in overcoming the drug resistance developed by several pathogenic microorganisms against most of the commonly used antibiotics. Compared with free antibiotic at the same concentration, drug delivered via a nanoparticle carrier has a much more prominent inhibitory effect on bacterial growth, and drug toxicity, along with prolonged drug release. Additionally, multiple drugs or antimicrobials can be packaged within the same smart polymer which can be designed with stimuli-responsive linkers. These stimuli-responsive nAbts open up the possibility of creating multipurpose and targeted antimicrobials. Biofilm formation still remains the leading cause of conventional antibiotic treatment failure. ...Continue Reading

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Jul 1, 2020·Advanced Materials·Rezvan JamaledinPooyan Makvandi
Oct 14, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Nawras OsmanThirumala Govender

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