Nanoarchitecturing of Natural Melanin Nanospheres by Layer-by-Layer Assembly: Macroscale Anti-inflammatory Conductive Coatings with Optoelectronic Tunability

Biomacromolecules
Taesik EomBong Sup Shim

Abstract

Natural melanins are biocompatible conductors with versatile functionalities. Here, we report fabrication of multifunctional poly(vinyl alcohol)/melanin nanocomposites by layer-by-layer (LBL) assembly using melanin nanoparticles (MNPs) directly extracted from sepia officinalis inks. The LBL assembly offers facile manipulation of nanotextures as well as nm-thickness control of the macroscale film by varying solvent qualities. The time-resolved absorption was monitored during the process and quantitatively studied by fractal dimension and lacunarity analysis. The capability of nanoarchitecturing provides confirmation of complete monolayer formation and leads to tunable iridescent reflective colors of the MNP films. In addition, the MNP films have durable electrochemical conductivities as evidenced by enhanced charge storage capacities for 1000 cycles. Moreover, the MNP covered ITO (indium tin oxide) substrates significantly reduced secretion of inflammatory cytokines, TNF-α, by raw 264.7 macrophage cells compared to bare ITO, by a factor of 5 and 1.8 with and without lipopolysaccharide endotoxins, respectively. These results highlight the optoelectronic device-level tunability along with the anti-inflammatory biocompatibility of ...Continue Reading

References

Mar 1, 1974·Science·J McGinnessP Proctor
Feb 6, 1998·The International Journal of Biochemistry & Cell Biology·P A Riley
May 24, 2003·Nature Materials·Zhiyong TangBirol Ozturk
Aug 5, 2003·Biomaterials·Bruce PanilaitisDavid L Kaplan
Oct 7, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Bong Sup Shim, Nicholas A Kotov
Mar 21, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Stéphanie VialLuis M Liz-Marzan
Oct 6, 2007·Science·Paul PodsiadloNicholas A Kotov
Dec 5, 2008·Accounts of Chemical Research·Sudhanshu Srivastava, Nicholas A Kotov
Feb 5, 2009·The European Physical Journal. E, Soft Matter·M AbbasR Gunnella
Mar 17, 2009·Biomaterials·Christopher J BettingerRobert Langer
Mar 19, 2009·Angewandte Chemie·Marco d'IschiaTadeusz Sarna
Jul 1, 1981·Applied Optics·M L WolbarshtG George
Mar 31, 2012·Journal of Materials Science. Materials in Medicine·Amir ZareidoostAmir Amanzadeh
May 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·Albertus B MostertPaul Meredith
Jun 22, 2012·Journal of the American Chemical Society·Hongjing WangYusuke Yamauchi
Jul 6, 2012·Journal of Theoretical Biology·Igor PanticVladimir Trajkovic
May 29, 2013·Pigment Cell & Melanoma Research·Marco d'IschiaShosuke Ito
Dec 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Young Jo KimChristopher J Bettinger
Apr 29, 2014·International Journal of Pharmaceutics·Marco AraújoAna Aguiar-Ricardo
Jul 2, 2014·Micron : the International Research and Review Journal for Microscopy·G PernaV Capozzi
Aug 27, 2014·Advanced Materials·Young Jo KimChristopher J Bettinger
Oct 24, 2014·Accounts of Chemical Research·Marco d'IschiaMarkus J Buehler
Jan 15, 2015·Biomacromolecules·Tong-Fei Wu, Jong-Dal Hong
Nov 19, 2015·The Journal of Physical Chemistry. B·Shermiyah B RieneckerPaul Meredith
Oct 18, 2016·Biomacromolecules·Yang WangMingqing Chen
Aug 21, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Julia WünscheClara Santato

❮ Previous
Next ❯

Citations

Oct 20, 2018·Advanced Materials·Nadav AmdurskyPaul Meredith
Dec 18, 2020·Frontiers in Bioengineering and Biotechnology·Jianqiao LiuYujin Tang
Feb 6, 2020·Acta Biomaterialia·Mariana CaldasVitor M Correlo
Feb 3, 2021·Healthcare·Seunghyeon LeeHyo-Bum Kwak
Feb 5, 2021·Science and Technology of Advanced Materials·Michinari Kohri
Feb 9, 2021·Global Challenges·Hanaa A GalebJohn G Hardy
Feb 28, 2020·The Journal of Physical Chemistry. B·Maher Al KhatibRebecca Pogni
Oct 13, 2020·ACS Omega·Yi-Chieh ChenJens U Sutter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.