Nanobiotechnology for the Therapeutic Targeting of Cancer Cells in Blood

Cellular and Molecular Bioengineering
Jiahe LiMichael R King

Abstract

During metastasis, circulating tumor cells migrate away from a primary tumor via the blood circulation to form secondary tumors in distant organs. Mounting evidence from clinical observations indicates that the number of circulating tumor cells (CTCs) in the blood correlates with the progression of solid tumors before and during chemotherapy. Beyond the well-established role of CTCs as a fluid biopsy, however, the field of targeting CTCs for the prevention or reduction of metastases has just emerged. Conventional cancer therapeutics have a relatively short circulation time in the blood which may render the killing of CTCs inefficient due to reduced exposure of CTCs to drugs. Nevertheless, over the past few decades, the development of nanoparticles and nanoformulations to improve the half-life and release profile of drugs in circulation has rejuvenated certain traditional medicines in the emerging field of CTC neutralization. This review focuses on how the principles of nanomedicine may be applied to target CTCs. Moreover, inspired by the interactions between CTCs and host cells in the blood circulation, novel biomimetic approaches for targeted drug delivery are presented.

References

Jul 1, 1990·The Journal of Pharmacy and Pharmacology·R KravtzoffM Chassaigne
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E ZocchiA De Flora
Jan 15, 1985·Biochemical Pharmacology·H O Alpar, D A Lewis
Sep 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·G M IhlerF W Schnure
Jan 1, 1996·European Journal of Clinical Pharmacology·R KravtzoffC Ropars
Jun 17, 2000·Science·P A OldenborgF P Lindberg
Mar 14, 2001·American Journal of Physiology. Cell Physiology·Q D WuH P Redmond
Aug 3, 2002·Nature Reviews. Cancer·Ann F ChambersIan C MacDonald
Sep 3, 2002·Advanced Drug Delivery Reviews·Irène BriggerPatrick Couvreur
Feb 15, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tatsuhiro IshidaHiroshi Kiwada
Jun 28, 2003·Trends in Molecular Medicine·Klaus Ley
Nov 19, 2003·Pharmaceutical Research·Yu-Chih HsuChing-An Peng
Dec 20, 2003·The EMBO Journal·Lorenzo Moretta, Alessandro Moretta
Mar 12, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Carmen Gutiérrez MillánJosé M Lanao
Aug 20, 2004·The New England Journal of Medicine·Massimo CristofanilliDaniel F Hayes
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·W Jeffrey AllardLeon W M M Terstappen
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Songdong MengJonathan W Uhr
Mar 18, 2005·Annual Review of Immunology·Lewis L Lanier
Sep 24, 2005·Journal of Cell Science·Derek C Radisky
Sep 28, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hiroshi Noguchi, Gerhard Gompper
Oct 20, 2005·Current Opinion in Chemical Biology·Alberto BiancoMaurizio Prato
Dec 2, 2005·Clinical & Experimental Metastasis·Jennifer J RahnJudith C Hugh
Dec 13, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·David D Kim, Wen-Chao Song
May 26, 2006·Nature Reviews. Cancer·Patrick Mehlen, Alain Puisieux
Feb 22, 2007·Blood·Shaun P Jackson
Apr 18, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ronald KoschnyTom M Ganten
May 10, 2007·Haematologica·Oleksii SkorokhodFazoil I Ataullakhanov
Jun 5, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Julie A ChampionSamir Mitragotri
Jul 6, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tatsuhiro IshidaHiroshi Kiwada
Nov 15, 2007·Seminars in Thrombosis and Hemostasis·Ali AmirkhosraviJohn L Francis
Nov 21, 2007·Journal of Nanoscience and Nanotechnology·Surya Singh, Hari Singh Nalwa
Dec 18, 2007·International Journal of Pharmaceutics·Tatsuhiro Ishida, Hiroshi Kiwada
Jul 26, 2008·Nature Nanotechnology·Yan GengDennis E Discher
Aug 5, 2008·Molecular Pharmaceutics·Frank AlexisOmid C Farokhzad
Aug 16, 2008·Journal of Nanobiotechnology·Francesco GentilePaolo Decuzzi
Oct 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Johann S de BonoDerek Raghavan

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Citations

Feb 28, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jiahe LiMichael R King
Sep 27, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Vidya GanapathyCharles M Roth
Oct 19, 2016·Contrast Media & Molecular Imaging·Sepideh KhaleghiHamid Reza Madaah Hosseini
Oct 14, 2016·Nucleic Acid Therapeutics·Eman M HassanMaria C DeRosa
Apr 14, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Marie-Emilie FrancartChristine Gilles
Feb 16, 2018·Clinical and Experimental Medicine·Chen QianHui Cong
May 26, 2018·Physical Biology·Tanishq AbrahamCheemeng Tan
Aug 31, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qiuxia YanYi Ma
Dec 26, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Catherine Alix-PanabièresKlaus Pantel
Aug 3, 2017·Acta Neuropathologica·Mohini SinghSheila K Singh
Apr 24, 2020·Drug Delivery and Translational Research·Sarah M KolaViness Pillay

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