Nanobubbles: a promising efficient tool for therapeutic delivery

Therapeutic Delivery
R CavalliMonica Argenziano

Abstract

In recent decades ultrasound-guided delivery of drugs loaded on nanocarriers has been the focus of increasing attention to improve therapeutic treatments. Ultrasound has often been used in combination with microbubbles, micron-sized spherical gas-filled structures stabilized by a shell, to amplify the biophysical effects of the ultrasonic field. Nanometer size bubbles are defined nanobubbles. They were designed to obtain more efficient drug delivery systems. Indeed, their small sizes allow extravasation from blood vessels into surrounding tissues and ultrasound-targeted site-specific release with minimal invasiveness. Additionally, nanobubbles might be endowed with improved stability and longer residence time in systemic circulation. This review will describe the physico-chemical properties of nanobubbles, the formulation parameters and the drug loading approaches, besides potential applications as a therapeutic tool.

References

Jun 1, 1997·Journal of Applied Physiology·H D Van Liew, S Raychaudhuri
Oct 29, 2000·Ultrasound in Medicine & Biology·O D KripfgansP L Carson
Apr 20, 2001·Advanced Drug Delivery Reviews·M P Krafft
Mar 17, 2005·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Jean G Riess
Jun 1, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Antonio CruzJesús Pérez-Gil
Jun 1, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Hélder A SantosKyösti Kontturi
Sep 24, 2005·Ultrasound in Medicine & Biology·Grzegorz KorpantyRolf A Brekken
Mar 22, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Gang PuMarjorie L Longo
Aug 9, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Ine LentackerNiek N Sanders
Nov 1, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Esra TaluMarjorie L Longo
Nov 23, 2006·Ultrasound in Medicine & Biology·Michaelann Shortencarier TartisKatherine W Ferrara
Dec 13, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·M EemanM Deleu
Apr 28, 2007·Journal of Colloid and Interface Science·Nina VankovaThomas Danner
Jul 12, 2007·Journal of the National Cancer Institute·Natalya RapoportAnne Kennedy
Nov 24, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ryo SuzukiKazuo Maruyama
May 13, 2008·Advanced Drug Delivery Reviews·William G Pitt, Ghaleb A Husseini
May 31, 2008·Science·Emilie DressaireHoward A Stone
Aug 20, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Francesca CavalieriFrank Caruso
Oct 28, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Klazina KooimanAnnemieke van Wamel
Nov 4, 2008·Journal of Pharmaceutical Sciences·Steliyan TinkovConrad Coester
Jan 22, 2009·Journal of Pharmaceutical Sciences·Tsong-Long HwangJia-You Fang
Feb 21, 2009·Physics in Medicine and Biology·Shengping QinKatherine W Ferrara
Apr 22, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Emmanouil GlynosVassilis Sboros
May 30, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Natalya Y RapoportKweon-Ho Nam
Jun 9, 2009·International Journal of Pharmaceutics·Roberta CavalliCaterina Guiot
Jul 21, 2009·International Journal of Pharmaceutics·R CavalliM Trotta
Nov 12, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Melvin E KlegermanDavid D McPherson
Dec 5, 2009·Molecular Pharmaceutics·Tianyi M KrupkaAgata A Exner
Jan 5, 2010·Bubble Science Engineering and Technology·Natalya Y RapoportKweon-Ho Nam
Mar 10, 2010·Journal of Biomedical Optics·Chulhong KimRonald Xu
Mar 12, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Madhuvanthi A KandadaiJules J Magda
Mar 13, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Meng AoYuanyi Zheng
May 18, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ryo SuzukiKazuo Maruyama
May 21, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Yukiko WatanabeTetsuya Kodama
Aug 17, 2010·Advanced Drug Delivery Reviews·Siti M JanibJ Andrew MacKay
Aug 31, 2010·Ultrasound in Medicine & Biology·Jose L TlaxcaJoshua J Rychak
Oct 5, 2010·International Journal of Pharmaceutics·Roberta CavalliPradeep Vavia
Dec 15, 2010·Journal of Biomaterials Science. Polymer Edition·Xiaoyan XiongYiyao Liu
Dec 15, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Elena Eva Julianne MarxerUdo Bakowsky
Jan 22, 2011·International Journal of Pharmaceutics·Behfar MoghaddamYvonne Perrie
Feb 1, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Natalya RapoportAnne M Kennedy
Mar 25, 2011·The Journal of the Acoustical Society of America·Philippe MarmottantCatherine Quilliet

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Citations

Jul 24, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Muhammad Saad KhanJonghoon Choi
Jul 31, 2020·Physical Chemistry Chemical Physics : PCCP·Gerald S Manning
Sep 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muhammad Saad KhanJonghoon Choi
Oct 2, 2019·Frontiers in Pharmacology·Sara ZullinoCaterina Guiot
Feb 23, 2020·Frontiers in Pharmacology·Xiaowen CaiChuanshan Xu
May 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eleonora FiciaràFederico D'Agata
Sep 16, 2020·Biomaterials Science·Andy WijayaGuixue Wang
Mar 23, 2018·Frontiers in Immunology·Blaise Corthésy, Gilles Bioley
Aug 5, 2020·Drug Delivery and Translational Research·Malobika Chakravarty, Amisha Vora
Dec 15, 2020·Therapeutic Delivery·Mathilde LorscheiderChristophe Chassaing
Jan 5, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bruna G CarvalhoLucimara G de la Torre
Dec 11, 2020·Food & Function·José David Sánchez-MartínezAlejandro Cifuentes
Mar 9, 2021·Bioconjugate Chemistry·Pinunta NittayacharnAgata A Exner
Aug 2, 2020·International Journal of Pharmaceutics·Manuela DonalisioRoberta Cavalli
May 12, 2021·Chemical Society Reviews·Ranhua XiongKevin Braeckmans
Jun 14, 2021·Advances in Colloid and Interface Science·Marie Pierre Krafft, Jean G Riess
Aug 31, 2021·ACS Biomaterials Science & Engineering·Kahkashan BansalHimanshu Shekhar
Sep 4, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Siya KamatC Jayabaskaran
Dec 10, 2021·Frontiers in Bioengineering and Biotechnology·Mingzhu ChenHong Quan

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Methods Mentioned

BETA
rheology
xenografts
xenograft
transfection
bioluminescence imaging
transfect

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