Nanocapsules: coating for living cells

IEEE Transactions on Nanobioscience
Silke KrolAlessandra Gliozzi

Abstract

One of the most promising tools for future applications in science and medicine is the use of nanotechnologies. Especially self-assembly systems, e.g., polyelectrolyte (PE) capsules prepared by means of the layer-by-layer technique with tailored properties, fulfill the requirements for nano-organized systems in a satisfactory manner. The nano-organized shells are suitable as coating for living cells or artificial tissue to prevent immune response. With these shells, material can be delivered to predefined organs. In this paper, some preliminary results are presented, giving a broad overview over the possibilities to use nano-organized capsules. Based on the observations that the cells while duplicating break the capsule a mutant yeast strain (Saccharomyces cerevisiae), which express GFP-tubulin under galactose promotion, was investigated by means of confocal laser scanning microscopy. The measurements reveal an increased surface charge in the region of buds developed prior encapsulation. In order to test the used PE pair for cytotoxicity, germinating conidia of the fungi Neurospora crassa were coated. The investigation with fluorescence microscopy shows a variation in the surface charge for the growing region and the conidium p...Continue Reading

References

Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·D OupickýL W Seymour
Mar 30, 2000·Journal of Microencapsulation·G B SukhorukovH Möhwald
Jun 6, 2000·Advanced Drug Delivery Reviews·R H Li
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May 16, 2006·IEEE Transactions on Nanobioscience·Alberto DiasproAlessandra Gliozzi

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Citations

Sep 5, 2006·IEE Proceedings. Nanobiotechnology·M Nolte, A Fery
May 3, 2007·Journal of Biomaterials Science. Polymer Edition·Michael GoldbergXinqiao Jia
May 31, 2011·Advanced Drug Delivery Reviews·Viviana VergaroStefano Leporatti
Nov 21, 2007·Advanced Drug Delivery Reviews·John T Wilson, Elliot L Chaikof
Sep 11, 2007·The Medical Clinics of North America·Rutledge Ellis-Behnke
Sep 28, 2010·Microscopy Research and Technique·Raffaella MagrassiAlberto Diaspro
Apr 8, 2006·Journal of Biotechnology·Tiziana Svaldo LaneroAlessandra Gliozzi
Oct 24, 2012·International Journal of Pharmaceutics·Min-Jeong ParkSu-Geun Yang
Dec 21, 2006·Journal of Biomaterials Science. Polymer Edition·Karel Petrak
Mar 11, 2010·Advanced Materials·Thomas BoudouCatherine Picart
Mar 27, 2019·Biomedizinische Technik. Biomedical Engineering·Moharram Habibnejad KorayemZahra Rastgear
May 9, 2012·Journal of Biomaterials Applications·Neda HabibiCarmelina Ruggiero
Jan 1, 2015·Chemical Science·Nan JiangBao-Lian Su
Jan 12, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Silke KrolAndreas Fery
Aug 12, 2009·Chemical Reviews·Stijn F M van DongenJan C M van Hest
Dec 15, 2005·Nano Letters·Munish ChananaSilke Krol

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