Nanocapsules of Sterculia striata acetylated polysaccharide as a potential monomeric amphotericin B delivery matrix

International Journal of Biological Macromolecules
Fernanda Matoso SombraRegina Célia Monteiro de Paula

Abstract

Stable oil nanocapsules based on acetylated Sterculia striata polysaccharide (ASSP) were produced without the use of a surfactant, and derivatives of ASSP with four different degrees of substitution (DS) were synthesised. The data revealed that only derivatives with high DS were able to produce nanocapsules (NC), which exhibited monomodal size distribution profiles with a Z-average particle size, ζ-potential, and polydispersity index (PDI) that were dependent on ASSP DS and concentration. Nanocapsules were loaded with amphotericin B (AMB) with encapsulation efficiencies (EE%) that were dependent on drug and ASSP concentrations and DS. A maximum EE% value of 99.2% was achieved, and the loaded AMB was found to be in a monomeric form, even with a concentration one hundredfold higher than that usually observed for commercial AMB aqueous solutions. Loaded nanocapsules show an in vitro controlled release of AMB. As the monomeric AMB state decreased drug toxicity, ASSP nanocapsules loaded with AMB (NC1.68) have potential for use as a drug delivery system. AMB loaded NC 1.68 keeps its activity against 5 strains of Candida albicans tested.

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Citations

Jan 8, 2020·Pharmaceutics·Célia Faustino, Lídia Pinheiro
Nov 18, 2019·International Journal of Biological Macromolecules·Fernanda M SombraRegina C M de Paula
Aug 6, 2021·Journal of Basic Microbiology·Saraswathi NagarajShoba Narayan
Nov 5, 2020·Carbohydrate Polymers·Solranny Carla Cavalcante Costa SilvaEdson C Silva-Filho

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