Nanocarbon-Based Glycoconjugates as Multivalent Inhibitors of Ebola Virus Infection

Journal of the American Chemical Society
Laura Rodríguez-PérezNazario Martín

Abstract

SWCNTs, MWCNTs, and SWCNHs have been employed as virus-mimicking nanocarbon platforms for the multivalent presentation of carbohydrates in an artificial Ebola virus infection model assay. These carbon nanoforms have been chemically modified by the covalent attachment of glycodendrons and glycofullerenes using the CuAAC "click chemistry" approach. This modification dramatically increases the water solubility of these structurally different nanocarbons. Their efficiency in blocking DC-SIGN-mediated viral infection by an artificial Ebola virus has been tested in a cellular experimental assay, finding that glycoconjugates based on MWCNTs functionalized with glycofullerenes are potent inhibitors of viral infection.

References

Sep 1, 1975·Analytical Biochemistry·M A Jermyn
Oct 26, 2001·Bioorganic & Medicinal Chemistry Letters·H KatoH Shinohara
Jun 7, 2002·Journal of Virology·Carmen P AlvarezRafael Delgado
Dec 18, 2002·Accounts of Chemical Research·M S DresselhausR Saito
Mar 21, 2003·Nature·Xiping WeiGeorge M Shaw
Sep 2, 2003·Nature Reviews. Immunology·Yvette van Kooyk, Teunis B H Geijtenbeek
Sep 3, 2003·Bioorganic & Medicinal Chemistry Letters·Yuji MikataShigenobu Yano
Nov 7, 2003·Organic Letters·Hiroyuki IsobeEiichi Nakamura
Nov 26, 2003·Antimicrobial Agents and Chemotherapy·Fátima LasalaRafael Delgado
May 13, 2004·Journal of the American Chemical Society·C A FurtadoPeter C Eklund
Mar 8, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·James P CollmanChristopher E D Chidsey
Sep 28, 2006·Journal of the American Chemical Society·B Katherine Price, James M Tour
Dec 29, 2006·Chemistry & Biodiversity·Yoshihiro NishidaKazukiyo Kobayashi
Jul 28, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Simone CiampiJ Justin Gooding
Oct 12, 2007·Biomaterials·Ander AbarrategiFrancisco del Monte
Jul 30, 2008·Journal of the American Chemical Society·Zhi ZhuWeihong Tan
Jul 1, 2009·Chembiochem : a European Journal of Chemical Biology·Olga Martínez-AvilaSoledad Penadés
Oct 8, 2009·Nature Nanotechnology·K KostarelosM Prato
Apr 24, 2010·Chemical Communications : Chem Comm·Jean-François NierengartenStéphane P Vincent
May 18, 2010·Nature Materials·Sung You HongBenjamin G Davis
Sep 8, 2010·Angewandte Chemie·Philippe CompainJean-François Nierengarten
Oct 20, 2010·Nanoscale·Shuyun Zhu, Guobao Xu
Nov 26, 2010·Chemical Communications : Chem Comm·Maxime DurkaStéphane P Vincent
Dec 8, 2010·Nano Letters·Harindra VedalaAlexander Star
Jan 13, 2011·Chemistry : a European Journal·Macarena Sánchez-NavarroNazario Martín
Nov 4, 2011·Chemical Communications : Chem Comm·María VizueteFernando Langa
Apr 11, 2012·Advanced Materials·Francesco RossellaMatteo Tommasini
Aug 23, 2012·Chemical Society Reviews·José L Jiménez BlancoJosé M García Fernández
Sep 7, 2012·Angewandte Chemie·Carlo FastingRainer Haag
Jan 4, 2013·Biomacromolecules·Joanna LuczkowiakJavier Rojo
Jan 8, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Minfang ZhangMasako Yudasaka

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Citations

Jan 16, 2019·Chemistry : a European Journal·Isabell WabraAndreas Hirsch
Sep 4, 2020·ChemPlusChem·Lili LiangGrzegorz Lisak
May 6, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Beatriz M IllescasNazario Martín
Sep 18, 2020·Pharmaceutics·Miguel Ángel OrtegaSandra García-Gallego
Feb 5, 2021·Advanced Drug Delivery Reviews·Will Stuart-Walker, Clare S Mahon
Mar 2, 2021·Advanced Materials·Si LiHua Kuang
Feb 4, 2021·Chemistry : a European Journal·Pilar HoyosMaría J Hernáiz
May 13, 2021·Chemical Communications : Chem Comm·Javier Ramos-Soriano, Javier Rojo
Apr 15, 2021·Chemistry : a European Journal·Marta Ruiz-SantaquiteriaNazario Martín
Jul 3, 2021·Nanomaterials·Noelia Losada-GarciaJose M Palomo
Jul 21, 2021·Journal of the American Chemical Society·Patricia Izquierdo-GarcíaNazario Martín
Aug 3, 2021·Chemical Reviews·Lu SuGuosong Chen
Aug 31, 2019·Journal of the American Chemical Society·Javier Ramos-SorianoNazario Martín
Nov 16, 2018·Journal of the American Chemical Society·Jesús M Fernández-GarcíaNazario Martín

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