Nanoclay-based drug delivery systems and their therapeutic potentials.

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Nafeesa KhatoonChun Hui Zhou

Abstract

Safe, therapeutically effective, and patient-compliant drug delivery systems are needed to design novel tools and strategies to combat the deadliest of diseases such as cancer, SARS, H7N9 avian influenza, and dengue infection. The major challenges in drug delivery are cytotoxicity, poor biodistribution, insufficient functionality, ineffective drug incorporation in delivery devices, and subsequent drug release. Clay minerals are a class of nanolayered silicates that have good biocompatibility, high specific surface area, chemical inertness, colloid, and thixotropy, and are attractive practical and potential nanomaterials in medicine. These properties enable the usage of nanoclays as drug carriers for the delivery of antibiotics, antihypertensive drugs, anti-psychotic, and anticancer drugs. The review examines the latest advances in nanoclay-based drug delivery systems and related applications in gene therapy and tissue engineering. Clay minerals, particularly montmorillonite, kaolinite, and halloysite are used to delay and/or target drug release or even improve drug dissolution due to their surface charge. Chemical modification of clay minerals such as intercalation of ions into the interlayer space of clay minerals or surface m...Continue Reading

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Citations

Dec 11, 2020·Expert Opinion on Drug Delivery·Jiani DongQubo Zhu
Feb 25, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xinyun ZhaiWilliam Weijia Lu
Jan 27, 2021·ACS Nano·Joshua SeabergPriyabrata Mukherjee
May 1, 2021·Polymers·Maria CantarellaSabrina Carola Carroccio
Jun 3, 2021·Materials·Anna KarewiczGabriela Ledwójcik
Aug 29, 2021·Pharmaceutics·Lisa MarinelliAntonio Di Stefano
Sep 21, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jiayu YuWei Jiang

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Methods Mentioned

BETA
dynamic
X-ray
scanning
transmission electron microscopy
light scattering
antisense oligodeoxynucleotides
transfection

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