Nanocomplexes of Photolabile Polyelectrolyte and Upconversion Nanoparticles for Near-Infrared Light-Triggered Payload Release

ACS Applied Materials & Interfaces
Jun XiangYue Zhao

Abstract

A new approach to encapsulating charged cargo molecules into a nanovector and subsequently using near-infrared (NIR) light to trigger the release is demonstrated. NIR light-responsive nanovector was prepared through electrostatic interaction-driven complexation between negatively charged silica-coated upconversion nanoparticles (UCNP@silica, 87 nm hydrodynamic diameter, polydispersity index ∼0.05) and a positively charged UV-labile polyelectrolyte bearing pendants of poly(ethylene glycol) and o-nitrobenzyl side groups; whereas charged fluorescein (FLU) was loaded through a co-complexation process. By controlling the amount of polyelectrolyte, UCNP@silica can be covered by the polymer, whereas remaining dispersed in aqueous solution. Under 980 nm laser excitation, UV light emitted by UCNP is absorbed by photolytic side groups within polyelectrolyte, which results in cleavage of o-nitrobenzyl groups and formation of carboxylic acid groups. Such NIR light-induced partial reversal of positive charge to negative charge on the polyelectrolyte layer disrupts the equilibrium among UCNP@silica, polyelectrolyte, and FLU and, consequently, leads to release of FLU molecules.

References

Oct 20, 2005·Journal of the American Chemical Society·Kyle N PlunkettJeffrey S Moore
Apr 6, 2007·Journal of the American Chemical Society·Yan LeeKazunori Kataoka
Sep 2, 2008·Nature Reviews. Drug Discovery·Mark E DavisDong M Shin
Nov 10, 2009·Nature Nanotechnology·Andrew M SmithShuming Nie
Jun 23, 2010·Journal of the American Chemical Society·Qiang YanYingwu Yin
Oct 18, 2011·Chemical Communications : Chem Comm·Bing YuJie Yin
Nov 16, 2011·Journal of the American Chemical Society·Bin YanYue Zhao
Nov 25, 2011·ACS Nano·Jun GeRichard N Zare
Dec 21, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Erez KorenVladimir P Torchilin
Jan 5, 2012·Chemical Society Reviews·Zongxi LiJeffrey I Zink
Feb 9, 2012·Advanced Materials·Damla KoyluSamuel W Thomas
Feb 1, 2013·Chemical Society Reviews·Jean-François Gohy, Yue Zhao
Oct 24, 2013·Nature Materials·Simona MuraPatrick Couvreur
Nov 26, 2013·Advanced Drug Delivery Reviews·Nicolas BertrandOmid C Farokhzad
Dec 20, 2013·Science Translational Medicine·Edward Kai-Hua Chow, Dean Ho
Jun 24, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Ruidong ChengJinqiang Jiang
Sep 9, 2015·Nature Biotechnology·Elvin BlancoMauro Ferrari
Sep 22, 2015·Advanced Materials·Si Wu, Hans-Jürgen Butt
Sep 24, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jason OlejniczakAdah Almutairi
Jul 13, 2016·Scientific Reports·Edoardo ScarpaTracey A Newman
Aug 3, 2016·ACS Applied Materials & Interfaces·Yangjun ChenQiao Jin
Aug 16, 2016·ACS Applied Materials & Interfaces·Xiaoran HuSamuel W Thomas

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Citations

Mar 23, 2019·Expert Opinion on Drug Delivery·Rafael R CastilloMaría Vallet-Regí
Apr 2, 2019·Chemistry : a European Journal·Jingjing YanShawn C Burdette
Aug 5, 2020·Journal of Nanobiotechnology·Xiaoying WangZongyu Xie
Oct 13, 2020·Analytical Methods : Advancing Methods and Applications·Hongqi ChenLun Wang
Feb 2, 2021·ACS Applied Materials & Interfaces·Jun XiangHaojun Fan
Dec 4, 2021·Photochemistry and Photobiology·Jinzhao LiuWeiping Wang

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