Nanocomposite Films of Chitosan-Grafted Carbon Nano-Onions for Biomedical Applications

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Carlos David Grande TovarManuel N Chaur

Abstract

The design of scaffolding from biocompatible and resistant materials such as carbon nanomaterials and biopolymers has become very important, given the high rate of injured patients. Graphene and carbon nanotubes, for example, have been used to improve the physical, mechanical, and biological properties of different materials and devices. In this work, we report the grafting of carbon nano-onions with chitosan (CS-g-CNO) through an amide-type bond. These compounds were blended with chitosan and polyvinyl alcohol composites to produce films for subdermal implantation in Wistar rats. Films with physical mixture between chitosan, polyvinyl alcohol, and carbon nano-onions were also prepared for comparison purposes. Film characterization was performed with Fourier Transformation Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC), Tensile strength, X-ray Diffraction Spectroscopy (XRD), and Scanning Electron Microscopy (SEM). The degradation of films into simulated body fluid (SBF) showed losses between 14% and 16% of the initial weight after 25 days of treatment. Still, a faster degradation (weight loss and pH changes) was obtained with composites of CS-g-CNO due to a higher SBF int...Continue Reading

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Citations

Nov 27, 2020·Biomaterials Science·Jyoti AhlawatMahesh Narayan
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jorge Iván CastroCarlos David Grande-Tovar

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Methods Mentioned

BETA
Infrared Spectroscopy
X-ray
Scanning
differential scanning calorimetry

Software Mentioned

TA Instruments Universal Analysis
Minitab

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