Nanocomposite scaffold with enhanced stability by hydrogen bonds between collagen, polyvinyl pyrrolidone and titanium dioxide

Colloids and Surfaces. B, Biointerfaces
Na LiBaoshi Wang

Abstract

In this study, three-dimensional (3D) nanocomposite scaffolds, as potential substrates for skin tissue engineering, were fabricated by freeze drying the mixture of type I collagen extracted from porcine skin and polyvinyl pyrrolidone (PVP)-coated titanium dioxide (TiO2) nanoparticles. This procedure was performed without any cross-linker or toxic reagents to generate porosity in the scaffold. Both morphology and thermal stability of the nanocomposite scaffold were examined. The swelling behavior, mechanical properties and hydrolytic degradation of the composite scaffolds were carefully investigated. Our results revealed that collagen, PVP and TiO2 are bonded together by four main hydrogen bonds, which is an essential action for the formation of nanocomposite scaffold. Using Coasts-Redfern model, we were able to calculate the thermal degradation apparent activation energy and demonstrated that the thermal stability of nanocomposites is dependent on amount of PVP incorporated. Furthermore, SEM images showed that the collagen fibers are wrapped and stabilized on scaffolds by PVP molecules, which improve the ultimate tensile strength (UTS). The UTS of PVP-contained scaffold is four times higher than that of scaffold without PVP, wh...Continue Reading

References

Jan 1, 1991·Critical Reviews in Food Science and Nutrition·L Slade, H Levine
Mar 17, 1999·Archives of Virology·T NemotoM Shinagawa
Aug 17, 1999·Journal of Biomedical Materials Research·P B van WachemM J van Luyn
May 10, 2002·Journal of Biomedical Materials Research·Julie E GoughSandra Downes
Apr 17, 2003·The Journal of Surgical Research·Carlos R Cervantes-SánchezFernando Edgar Krötzsch
Jan 14, 2004·Canadian Journal of Physiology and Pharmacology·Janette Furuzawa-CarballedaEdgar Krötzsch
Jul 29, 2005·Environmental Science & Technology·Xue-pin Liao, Bi Shi
Sep 27, 2005·International Journal of Biological Macromolecules·B MadhanT Ramasami
Jun 7, 2007·Journal of the American Chemical Society·Michael A BryanRichard Mendelsohn
Aug 19, 2007·Biochimica Et Biophysica Acta·Andreas Barth
Oct 31, 2008·Biomacromolecules·Luciano CastanedaKatarzyna Slowinska
Sep 7, 2012·ACS Applied Materials & Interfaces·William A McMasterRachel A Caruso

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Citations

Jul 28, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Young-Jae KimJin-Kyu Lee
Jan 24, 2017·International Journal of Biological Macromolecules·Shazia TabasumKhalid Mahmood Zia
Oct 6, 2018·Journal of Biomedical Materials Research. Part a·Dhivyaa AnandanAmit Kumar Jaiswal
Apr 16, 2019·Frontiers in Pediatrics·Maya HorstSouzan Salemi
May 5, 2020·Frontiers in Bioengineering and Biotechnology·Abdel Rahman Abdel Fattah, Adrian Ranga
Apr 9, 2020·International Journal of Molecular Sciences·Jana PryjmakováJakub Siegel
Jan 12, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Mohan VedhanayagamKalarical Janardhanan Sreeram
Dec 5, 2020·Journal of Biomedical Research·Xiaowei Liu, Fumihiko Nakamura
Jan 16, 2020·ACS Applied Materials & Interfaces·Hak-Sung JungKeir C Neuman

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