Nanocurcumin: A novel strategy in treating ankylosing spondylitis by modulating Th17 cells frequency and function

Journal of Cellular Biochemistry
Mehrzad HajialiloMehdi Yousefi

Abstract

Ankylosing spondylitis (AS) is a chronic rheumatic disease which mainly affects the axial skeleton and sacroiliac joints. T-helper 17 (Th17) cells have been reportedly involved in AS pathogenesis. Nanocurcumin is considered to be beneficial, as an anti-inflammatory compound, in AS patients treatment. In this study, Th17-related immunological parameters were evaluated in AS patients. Transcription factors messenger RNA (mRNA) expression level, cytokines, and related microRNAs (miRNAs) were measured by real-time polymerase chain reaction. Additionally, Th17 frequency and cytokines secretion were evaluated by flow cytometry and enzyme-linked immunosorbent assay tests, respectively. The frequency of Th17 was higher in AS patients. Gained data from nanocurcumin group also demonstrated that retinoic acid-related orphan receptor γ (RORγt) and interleukin-17 (IL-17) mRNA expression levels were significantly decreased (P = 0.0001 and 0.0006, respectively), as the decrease also happened in Th17-associated miRNAs including miR-141, miR-155, and miR-200 ( P = 0.04, P = 0.02, and P < 0.0001, respectively). Posttreatment data of miR-155 and miR-200 in the nanocurcumin and placebo groups also showed a higher expression level in the placebo gr...Continue Reading

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Citations

Aug 21, 2019·Phytotherapy Research : PTR·Arash KarimiAli Tarighat-Esfanjani
Oct 9, 2019·Journal of Biochemical and Molecular Toxicology·Dongmei MaoQi Zhang
Apr 30, 2020·Environmental Science and Pollution Research International·Mohamed AfifiAaser M Abdelazim
Dec 30, 2020·Journal of Cellular Physiology·Safa TahmasebiMajid Ahmadi
Apr 1, 2021·Life Sciences·Safa TahmasebiLeila Roshangar

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