Nanodiamond Coating Improves the Sensitivity and Antifouling Properties of Carbon Fiber Microelectrodes

ACS Sensors
Pumidech Puthongkham, B Jill Venton

Abstract

Nanodiamonds (NDs) are carbon nanomaterials with a core diamond crystalline structure and crystal defects, such as graphitic carbon and heteroatoms, on their surface. For electrochemistry, NDs are promising to increase active sites and decrease fouling, but NDs have not been studied for neurotransmitter electrochemistry. Here, we optimized ND coatings on microelectrodes and found that ND increases the sensitivity for neurotransmitters with fast-scan cyclic voltammetry detection and decreases electrochemical and biofouling. Different sizes and functionalizations of NDs were tested, and ND suspensions were drop-casted onto carbon-fiber microelectrodes (CFMEs). The 5 nm ND-H and 5 nm ND-COOH formed thick coatings, while the 15 and 60 nm ND-COOH formed more sparse coatings. With electrochemical impedance spectroscopy, 5 nm ND-H and 5 nm ND-COOH had high charge-transfer resistance, while 15 and 60 nm ND-COOH had low charge-transfer resistance. ND-COOH (15 nm) was optimal, with the best electrocatalytic properties and current for dopamine. Sensitivity was enhanced 2.1 ± 0.2 times and the limit of detection for dopamine improved to 3 ± 1 nM. ND coating increased current for other cations such as serotonin, norepinephrine, and epinephr...Continue Reading

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Citations

Jan 11, 2020·The Analyst·Pumidech Puthongkham, B Jill Venton
May 27, 2020·Chemical Communications : Chem Comm·Yuxin LiAshley E Ross
Jul 4, 2020·Analytical Methods : Advancing Methods and Applications·Yuanyu Chang, B Jill Venton
Apr 6, 2020·Analytical and Bioanalytical Chemistry·G MoroK De Wael
Jun 23, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Changhoon SungSeongjun Park
Mar 7, 2021·Micromachines·Chao TanXinyan Tracy Cui
Jun 26, 2021·Advanced Healthcare Materials·Jessica S L FongAmy Gelmi
Jun 26, 2021·Biosensors & Bioelectronics·Elisa CastagnolaXinyan Tracy Cui
Aug 18, 2021·Journal of Neural Engineering·Mamta DeviSwati Sharma

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