Nanoemulsion-based delivery systems for poorly water-soluble bioactive compounds: Influence of formulation parameters on Polymethoxyflavone crystallization

Food Hydrocolloids
Yan LiD Julian McClements


Polymethoxyflavones (PMFs) extracted from citrus peel exhibit potent anti-cancer activity, but are highly hydrophobic molecules with poor solubility in both water and oil at ambient and body temperature, which limits their bioavailability. The possibility of encapsulating PMFs within nanoemulsion-based delivery systems to facilitate their application in nutraceutical and pharmaceutical products was investigated. The influence of oil type (corn oil, MCT, orange oil), emulsifier type (β-lactoglobulin, lyso-lecithin, Tween, and DTAB), and neutral cosolvents (glycerol and ethanol) on the formation and stability of PMF-loaded nanoemulsions was examined. Nanoemulsions (r < 100 nm) could be formed using high pressure homogenization for all emulsifier types, except DTAB. Lipid droplet charge could be altered from highly cationic (DTAB), to near neutral (Tween), to highly anionic (β-lactoglobulin, lyso-lecithin) by varying emulsifier type. PMF crystals formed in all nanoemulsions after preparation, which had a tendency to sediment during storage. The size, morphology, and aggregation of PMF crystals depended on preparation method, emulsifier type, oil type, and cosolvent addition. These results have important implications for the develo...Continue Reading


Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Rainer H MüllerSven Gohla
Nov 7, 2003·Journal of Pharmaceutical Sciences·Ping GaoMichael J Hageman
Apr 15, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·R Neslihan Gursoy, Simon Benita
Apr 28, 2004·Advanced Drug Delivery Reviews·S A WissingRainer H Müller
May 25, 2005·The Journal of Chemical Physics·Daniel L Feltham, John Garside
Mar 8, 2006·Molecular Nutrition & Food Research·Shiming LiChi-Tang Ho
Jun 8, 2006·Journal of Agricultural and Food Chemistry·Shiming LiChi-Tang Ho
Jul 4, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Colin W Pouton
Oct 19, 2006·Life Sciences·Igor N SergeevSlavik Dushenkov
Mar 3, 2007·Nature Reviews. Drug Discovery·Christopher J H PorterWilliam N Charman
Dec 7, 2007·The Journal of Pharmacy and Pharmacology·Paolo BovicelliDaniela Lambusta
Dec 11, 2007·Advanced Drug Delivery Reviews·Colin W Pouton, Christopher J H Porter
Jun 20, 2008·Journal of Colloid and Interface Science·Lennart LindforsUlf Olsson
Oct 15, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·T J WoosterPeerasak Sanguansri
Apr 18, 2009·Journal of Pharmaceutical Sciences·Joachim BrouwersPatrick Augustijns
Jun 10, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Subhashis ChakrabortySanjay Singh
Nov 17, 2009·Advances in Colloid and Interface Science·Eveline FredrickKoen Dewettinck
Jan 8, 2010·Combinatorial Chemistry & High Throughput Screening·Michael J Hageman
Mar 11, 2010·International Journal of Pharmaceutics·W AliC F Rawlinson
Apr 3, 2010·Archives of Pharmacal Research·Jeoung Hee YooKun Han
Jul 20, 2010·Advances in Colloid and Interface Science·D Julian McClements, Yan Li
Jul 28, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Saipin SetthacheewakulRuedeekorn Wiwattanapatapee
Aug 24, 2010·Drug Discovery Today·Kanchan KohliRoop K Khar
Sep 17, 2010·Journal of Pharmaceutical Sciences·Jan BevernagePatrick Augustijns
Nov 3, 2010·The Journal of Pharmacy and Pharmacology·Anette MüllertzThomas Rades
Mar 25, 2011·Critical Reviews in Food Science and Nutrition·D Julian McClements, Jiajia Rao
Jan 1, 2010·Annual Review of Food Science and Technology·D Julian McClements


Jan 22, 2013·Journal of Agricultural and Food Chemistry·Ayse KaradagQingrong Huang
Aug 7, 2013·Journal of Agricultural and Food Chemistry·Yuwen TingQingrong Huang
Jan 21, 2014·Ultrasonics Sonochemistry·Shabbar AbbasXiaoming Zhang
Dec 1, 2015·Journal of Agricultural and Food Chemistry·Jingjing ChenHang Xiao
Mar 5, 2016·Journal of Agricultural and Food Chemistry·Max BatenburgRobin Gouka
Apr 6, 2012·Advances in Colloid and Interface Science·D Julian McClements
Aug 13, 2013·Pharmaceutical Development and Technology·Ana S MacedoEliana B Souto
Mar 7, 2014·Journal of Oleo Science·Md Khalid AnwerFaiyaz Shakeel
Jun 27, 2015·Critical Reviews in Food Science and Nutrition·P KarthikC Anandharamakrishnan
Apr 8, 2015·Critical Reviews in Food Science and Nutrition·Jake McClements, D Julian McClements
May 15, 2013·Progress in Lipid Research·D Julian McClements
Dec 30, 2014·Journal of Agricultural and Food Chemistry·Yuwen TingQingrong Huang
Sep 30, 2016·Critical Reviews in Biotechnology·Brahma N SinghKhabat Vahabi
Dec 18, 2013·Annual Review of Food Science and Technology·Mingfei YaoD Julian McClements
Sep 10, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Niyaz AhmadMastour Safer Al-Ghamdi
Feb 10, 2017·Journal of Agricultural and Food Chemistry·Ying YangJinkai Zheng
Jan 27, 2017·Annual Review of Food Science and Technology·Laura Salvia-TrujilloOlga Martín-Belloso
Jul 28, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Daoxiao ChangWenping Wang
Sep 20, 2018·Journal of Food Science and Technology·Priscilla Pereira Dos SantosAlessandro de Oliveira Rios
Dec 1, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sued Eustáquio Mendes MirandaAndre Luis Branco de Barros
Dec 15, 2020·Natural Product Research·Maiara Callegaro VelhoAline Ferreira Ourique

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