Nanoemulsion Stabilized by Safe Surfactin from Bacillus Subtilis as a Multifunctional, Custom-Designed Smart Delivery System

Pharmaceutics
Agnieszka LewińskaMarcin Łukaszewicz

Abstract

The developing field of bio-nanotechnology aims to advance colloidal research via the introduction of multifunctional nanoparticles to augment the dermal effectiveness of active substances. Self-emulsifying drug delivery systems (SEDDS)-isotropic mixtures of oils, surfactants, solvents and co-solvents or surfactants-are attracting interest in the cosmeceutical field. As part of this study, SEDDS systems containing vitamin C or vitamin E and curcumin were developed, whereby the bioavailability of the active compounds increased by enhancing their permeability to deeper layers of the skin. A composition consisting of 50% surfactin from Bacillus subtilis, 30% Transcutol and 20% oil phase was designed to encapsulate the active substances, i.e., vitamin C or vitamin E and curcumin, contained in the oil phase. The developed carriers were characterized by average particle sizes of 69-183 nm. The formulations with the vitamins were found to be physically and chemically stable for 6 months. Transdermal tests were carried out, showing that the carriers enable the transport of active substances deep into the skin, stopping at the dermis border. The formulations with vitamin C and vitamin E reduced the discoloration, the vascular lesions, a...Continue Reading

References

Jan 1, 1991·Free Radical Biology & Medicine·C K Chow
Jan 1, 1996·Skin Pharmacology : the Official Journal of the Skin Pharmacology Society·F Levi-SchafferE Touitou
Nov 4, 2000·Dermatologic Clinics·A M Kligman
Aug 18, 2001·Skin Pharmacology and Applied Skin Physiology·J Hadgraft
Apr 14, 2004·Current Medicinal Chemistry·Shosuke Kojo
Jul 3, 2004·International Journal of Dermatology·Kabir SardanaVirendra N Sehgal
Jul 21, 2005·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jens J ThieleSwarna Ekanayake-Mudiyanselage
Jul 21, 2005·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Patricia K Farris
Jan 19, 2006·International Journal of Biological Macromolecules·Sang-Ho YooHyeon Gyu Lee
May 11, 2006·Skin Pharmacology and Physiology·H Trommer, R H H Neubert
Dec 14, 2006·Journal of Cosmetic Dermatology·C RonaE Berardesca
Aug 28, 2007·Molecular Aspects of Medicine·Jens J Thiele, Swarna Ekanayake-Mudiyanselage
Mar 21, 2009·Journal of Cutaneous Medicine and Surgery·Seon-Wook HwangSung-Wook Park
Aug 21, 2009·Journal of Burn Care & Research : Official Publication of the American Burn Association·Eliana BarbosaDanilo Wilhelm Filho
Feb 9, 2010·Critical Reviews in Therapeutic Drug Carrier Systems·Bhupinder SinghO Katare
Jun 19, 2012·International Journal of Pharmaceutics·Gopinathan K MenonMajella E Lane
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
Apr 16, 2013·Antioxidants & Redox Signaling·James M May, Fiona E Harrison
Oct 29, 2013·Clinics in Dermatology·Marcia Ramos-e-SilvaAna Paula Fucci-da-Costa
May 17, 2015·Regulatory Toxicology and Pharmacology : RTP·Francesca Larese FilonMatteo Crosera
Jun 10, 2016·Critical Reviews in Therapeutic Drug Carrier Systems·Rohit KarwalTanmay S Markandeywar
Dec 19, 2016·Materials Science & Engineering. C, Materials for Biological Applications·José M LanderosPatricia Guadarrama
Feb 28, 2018·Pharmaceutical Research·Janneke Keemink, Christel A S Bergström
May 1, 2018·Journal of Cosmetic Dermatology·Anna JarosHelena Rotsztejn
May 18, 2019·Microscopy Research and Technique·Ida Dulińska-MolakIrena Eris
Nov 30, 2019·Colloids and Surfaces. B, Biointerfaces·Agnieszka LewińskaJulia Jezierska
Feb 6, 2020·Pharmaceutics·Christofori M R R NastitiHeather A E Benson

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Citations

Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Agnieszka LewińskaMarcin Łukaszewicz
May 24, 2021·Advances in Colloid and Interface Science·Lucia SalvioniMiriam Colombo
Jun 26, 2021·Critical Reviews in Biotechnology·Marcia Nitschke, Crisiane Aparecida Marangon

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Methods Mentioned

BETA
dynamic light scattering
X-ray
scanning electron microscopy
transmission microscopy
confocal microscopy

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