Nanoemulsions as vehicles for topical administration of glycyrrhetic acid: characterization and in vitro and in vivo evaluation

Drug Delivery
Carmelo PugliaFrancesco Bonina

Abstract

Nano-emulsions are innovative colloidal systems characterized by high kinetic stability, low viscosity, and optical transparency, which make them very attractive in many dermatological applications. Furthermore their small size seems to favor the topical administration of actives which scarcely cross the skin. In the light of these interesting features, the present study was aimed to the evaluation, in vitro and in vivo, of glycyrrhetic acid (GA) release through the skin from the nanoemulsion system. GA-loaded nanoemulsion (GA(N)) was prepared by phase inversion temperature (PIT) method, and was characterized in order to determine mean droplet size and its stability during a well-defined storage period. Further Cryo-TEM studies were performed to obtain information regarding nanoemulsion structure. The GA release pattern from nanoemulsion was evaluated in vitro, to determine its percutaneous absorption through excised human skin (stratum corneum and epidermis, SCE), and in vivo evaluating GA topical anti-inflammatory activity on healthy human volunteers by the UVB-induced erythema model. Nanoemulsions prepared by PIT method showed a mean droplet diameter of 210 nm that drastically changed during a storage of 5 weeks at room temp...Continue Reading

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Citations

Nov 15, 2011·Drug Development and Industrial Pharmacy·Shuang LiYunhua Gao
Jun 19, 2012·Expert Opinion on Drug Delivery·Faiyaz ShakeelIbrahim A Alsarra
Jan 10, 2013·International Journal of Pharmaceutics·Abdelbary ElhissiKevin M G Taylor
Feb 15, 2011·Advanced Drug Delivery Reviews·Tarl W ProwMichael S Roberts
Mar 22, 2020·Pharmaceutics·Larisa KolevaElena Sinauridze
Dec 28, 2019·Current Pharmaceutical Design·Cinzia PaganoMaurizio Ricci
Jan 25, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Francesca PierigèMauro Magnani
Oct 5, 2019·Current Pharmaceutical Design·Carmelo Puglia, Debora Santonocito
Nov 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Roxana JijieSabine Szunerits
Mar 19, 2020·Current Pharmaceutical Design·Md A BarkatFarhan J Ahmad
Sep 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daizo MorikaneNorihiro Nishimura
May 5, 2021·Indian Journal of Dermatology, Venereology and Leprology·Sujata Pralhad Sawarkar, Vijay Yadav
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marta Salvador FerreiraIsabel Filipa Almeida
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Debora SantonocitoMaria Grazia Sarpietro

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