Nanofiber-microsphere (nano-micro) matrices for bone regenerative engineering: a convergence approach toward matrix design

Regenerative Biomaterials
Clarke NelsonCato T Laurencin

Abstract

Bone is an essential organ for health and quality of life. Due to current shortfalls in therapy for bone tissue engineering, scientists have sought the application of synthetic materials as bone graft substitutes. As a composite organic/inorganic material with significant extra cellular matrix (ECM), one way to improve bone graft substitutes may be to engineer a synthetic matrix that is influenced by the physical appearance of natural ECM networks. In this work, the authors evaluate composite, hybrid scaffolds for bone tissue engineering based on composite ceramic/polymer microsphere scaffolds with synthetic ECM-mimetic networks in their pore spaces. Using thermally induced phase separation, nanoscale fibers were deposited in the pore spaces of structurally sound microsphere-based scaffold with a density proportionate to the initial polymer concentration. Porosimetry and mechanical testing indicated no significant changes in overall pore characteristics or mechanical integrity as a result of the fiber deposition process. These scaffolds displayed adequate mechanical integrity on the scale of human trabecular bone and supported the adhesion and proliferation of cultured mouse calvarial osteoblasts. Drawing from natural cues, the...Continue Reading

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Citations

Sep 1, 2016·ACS Applied Materials & Interfaces·Zhaozhao DingDavid L Kaplan
Jun 22, 2017·Annual Review of Biomedical Engineering·Vineet GuptaMichael S Detamore
Jan 29, 2019·Regenerative Engineering and Translational Medicine·Clarke NelsonCato T Laurencin
Jun 2, 2016·Nanomedicine·Roshan James, Cato T Laurencin
Mar 12, 2018·ACS Biomaterials Science & Engineering·Ganesh NarayananCato T Laurencin
Aug 20, 2021·Regenerative Biomaterials·Yixin ZhangJing Xie

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Methods Mentioned

BETA
scanning electron microscopy
confocal microscopy

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