Aug 28, 2007

Nanofibers and their applications in tissue engineering

International Journal of Nanomedicine
Rajesh Vasita, Dhirendra S Katti

Abstract

Developing scaffolds that mimic the architecture of tissue at the nanoscale is one of the major challenges in the field of tissue engineering. The development of nanofibers has greatly enhanced the scope for fabricating scaffolds that can potentially meet this challenge. Currently, there are three techniques available for the synthesis of nanofibers: electrospinning, self-assembly, and phase separation. Of these techniques, electrospinning is the most widely studied technique and has also demonstrated the most promising results in terms of tissue engineering applications. The availability of a wide range of natural and synthetic biomaterials has broadened the scope for development of nanofibrous scaffolds, especially using the electrospinning technique. The three dimensional synthetic biodegradable scaffolds designed using nanofibers serve as an excellent framework for cell adhesion, proliferation, and differentiation. Therefore, nanofibers, irrespective of their method of synthesis, have been used as scaffolds for musculoskeletal tissue engineering (including bone, cartilage, ligament, and skeletal muscle), skin tissue engineering, vascular tissue engineering, neural tissue engineering, and as carriers for the controlled deliv...Continue Reading

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  • Citations151

Citations

Mentioned in this Paper

Skin Tissue
Drug Delivery Systems
Ligaments
Blood Vessel
Cell Culture Techniques
Articular Ligaments
Particle Size
Cell Differentiation Process
Cell Adhesion
Mimic brand of tebufenozide

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