Nanofibers based antibacterial drug design, delivery and applications

Current Pharmaceutical Design
Kezban UlubayramIpek Eroglu

Abstract

Infections caused by microorganisms like bacteria, fungi, etc. are the main obstacle in healing processes. Conventional antibacterial administration routes can be listed as oral, intravenous/intramuscular, topical and inhalation. These kinds of drug administrations are faced with critical vital issues such as; more rapid delivery of the drug than intended which can result in bacterial resistance, dose related systemic toxicity, tissue irritation and finally delayed healing process that need to be tackled. Recently, studies have been focused on new drug delivery systems, overcoming resistance and toxicological problems and finally localizing the molecules at the site of action in a proper dose. In this regard, many nanotechnological approaches such as nanoparticulate therapeutic systems have been developed to address accompanying problems mentioned above. Among them, drug loaded electrospun nanofibers propose main advantages like controlled drug delivery, high drug loading capacity, high encapsulation efficiency, simultaneous delivery of multiple drugs, ease of production and cost effectiveness for pharmaceutical and biomedical applications. Therefore, some particular attention has been devoted to the design of electrospun nanof...Continue Reading

Citations

Feb 7, 2017·Expert Opinion on Drug Discovery·Semih CalamakKezban Ulubayram
Nov 9, 2019·Advanced Healthcare Materials·Bahareh AzimiSerena Danti
Feb 11, 2018·Journal of Biomedical Materials Research. Part a·Ulku Selcen DemirKezban Ulubayram
Oct 5, 2021·Journal of Biomaterials Science. Polymer Edition·Deepika SharmaBhabani K Satapathy

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