Nanofibrous scaffold from self-assembly of beta-sheet peptides containing phenylalanine for controlled release

Journal of Controlled Release : Official Journal of the Controlled Release Society
Ying ZhaoTianwei Tan

Abstract

Scaffold nanostructures from self-assembly of beta-sheet peptides, RADAFI and RADAFII, containing same amino acid compositions but different positions of one phenylalanine residue, were investigated. Atomic force microscopy (AFM) images clearly showed that peptide RADAFI self-assembled into twisted nanofibers with multiple molecular sized width and height, but no twisted nanofiber, characterized by a stacked bilayer model with single molecular sized width, was obtained in RADAFII scaffold. Two models of the hierarchical self-assembling behaviors could be illustrated for RADAFI and RADAFII scaffolds. The peptide scaffolds might also be promising for a variety of possible biomedical applications, including drug delivery, and the results revealed some relationships among the peptide sequence, the network nanoarchitecture, and the controlled release. From the remarkably large difference between the architecture and properties of the self-assembling materials based on the two similar peptides, it could be concluded that the self-assembly behaviors were delicate and could be dramatically altered by small modifying peptide structural features due to subtle changing the phenyl group position. The presence of a center pi-pi stacking bet...Continue Reading

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Citations

Jan 5, 2011·Microbial Cell Factories·Esther Vázquez, Antonio Villaverde
Jul 25, 2012·Therapeutic Delivery·Sarah-Jane RymerClive J Roberts
Jan 15, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ying ZhaoGuangjun Nie
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Feb 8, 2018·ACS Applied Materials & Interfaces·Yingqiu QiGuangjun Nie

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