Nanofibrous vascular scaffold prepared from miscible polymer blend with heparin/stromal cell-derived factor-1 alpha for enhancing anticoagulation and endothelialization

Colloids and Surfaces. B, Biointerfaces
Weizhong WangChuanglong He

Abstract

There is an urgent clinical demand to develop a functional small diameter vascular graft with long-term patency, which mainly relies on the anticoagulation and endothelialization of the vascular graft. In addition, improved degradation of vascular graft provides more space for cell infiltration and facilitates remodeling of blood vessel. In this study, an elastic and biomimetic nanofibrous vascular scaffold with improved degradability was prepared by adding poly(lactic-co-glycolic acid) (PLGA) into the poly(L-lactic acid) (PLLA)/poly(L-lactide-co-ε-caprolactone) (PLCL) blend using thermally induced phase separation (TIPS) technique. The incorporation of PLGA also improved the hydrophilicity of the composite scaffold. Then the vascular scaffold was surface modified by combination of heparin and stromal cell-derived factor-1 alpha (SDF-1α). The results of whole blood clotting kinetics and plasma recalcification profiles indicated that heparinized modification significantly enhanced the anticoagulation of vascular scaffold. In vitro cell culture assays demonstrated the immobilized SDF-1α facilitated recruitment of endothelial progenitor cells (EPCs), migration and proliferation of mature endothelial cells, human umbilical vein end...Continue Reading

Citations

Jun 9, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yizao WanHonglin Luo
Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Quanchao ZhangYizao Wan
Mar 7, 2021·International Journal of Biological Macromolecules·Pablo C CaraccioloCarmen Alvarez-Lorenzo
Apr 20, 2021·Advanced Healthcare Materials·Chao Tao, Dong-An Wang
Jun 5, 2021·Frontiers in Chemistry·Antonio Junior LepeddaLorenzo Moroni

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.