Abstract
Conventional systemic immunotherapy administration often results in insufficient anti-tumor immune response and adverse side effects. Delivering immunotherapeutics intratumorally could maximize tumor exposure, elicit efficient anti-tumor immune response, and minimize toxicity. To fulfill the unmet clinical need for sustained local drug delivery and to avoid repeated intratumoral injections, we developed a nanofluidic-based device for intratumoral drug delivery called the nanofluidic drug-eluting seed (NDES). The NDES is inserted intratumorally using a minimally invasive trocar method similar to brachytherapy seed insertion and offers a clinical advantage of drug elution. Drug diffusion from the NDES is regulated by physical and electrostatic nanoconfinement, thereby resulting in constant and sustained immunotherapeutic delivery without the need for injections or clinician intervention. In this study, the NDES was used to deliver immunotherapeutics intratumorally in the 4 T1 orthotopic murine mammary carcinoma model, which recapitulates triple negative breast cancer. We demonstrated that NDES-mediated intratumoral release of agonist monoclonal antibodies, OX40 and CD40, resulted in potentiation of local and systemic anti-tumor i...Continue Reading
Citations
Nov 15, 2018·Chembiochem : a European Journal of Chemical Biology·Vincent HuynhRyan G Wylie
Jun 7, 2019·Lab on a Chip·Nicola Di TraniAlessandro Grattoni
Jul 25, 2019·Cancers·Gabrielle Planes-LaineAnthony Gonçalves
Apr 7, 2020·Lab on a Chip·Nicola Di TraniAlessandro Grattoni
Apr 8, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Peter AbdouZhen Gu
May 20, 2019·Biomedical Microdevices·Fernanda P Pons-FaudoaAlessandro Grattoni
Oct 9, 2019·Nature Reviews. Clinical Oncology·Oliver KeppGuido Kroemer
Oct 20, 2020·Advanced Therapeutics·Corrine Ying Xuan ChuaAlessandro Grattoni
Oct 22, 2020·Pharmaceutics·Fernanda P Pons-FaudoaAlessandro Grattoni
Dec 5, 2020·Expert Opinion on Drug Delivery·Ashley R JohnsonStephanie E Barrett
Jan 30, 2021·Life Sciences·Nastaran HashemzadehJaleh Barar
Mar 3, 2021·Biomaterials·Corrine Ying Xuan ChuaAlessandro Grattoni
Aug 28, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiao ZhuLiao Cui
Apr 4, 2021·Pharmaceutics·Zhiwei ZhangJingwen Luo
Aug 10, 2020·International Journal of Radiation Oncology, Biology, Physics·Hsuan-Chen LiuAlessandro Grattoni
Jun 26, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Nicola Di TraniAlessandro Grattoni
Aug 6, 2021·Drug Delivery and Translational Research·Seung Woo ChungJung Soo Suk
Feb 19, 2020·ACS Applied Materials & Interfaces·Nicola Di TraniAlessandro Grattoni
Sep 7, 2018·ACS Applied Materials & Interfaces·Giovanni ScorranoAlessandro Grattoni
Nov 10, 2021·Nanomedicine·Fengjie LiuYu Cai