Nanofluidic redox cycling amplification for the selective detection of catechol

Analytical Chemistry
Bernhard L WolfrumSerge G Lemay

Abstract

We have developed a chip-based nanofluidic device to amplify the electrochemical signal of catechols by orders of magnitude. The amplification is based on rapid redox cycling between plane parallel electrodes inside a nanochannel. We show that it is possible to monitor the signal of only a few hundred molecules residing in the active area of the nanofluidic sensor. Furthermore, due to the nanochannel design, the sensor is immune to interference by molecules undergoing irreversible redox reactions. We demonstrate the selectivity of the device by detecting catechol in the presence of ascorbic acid, whose oxidized form is only stable for a short time. The interference of ascorbic acid is usually a challenge in the detection of catecholamines in biological samples.

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Citations

Jan 7, 2009·Analytical and Bioanalytical Chemistry·Edgar D GoluchSerge G Lemay
May 14, 2014·Annual Review of Analytical Chemistry·Karen Dawson, Alan O'Riordan
May 11, 2010·Journal of Electroanalytical Chemistry·Gregory S McCartyMatthew K Zachek
May 23, 2015·Biosensors & Bioelectronics·Junshan LiuLiding Wang
Sep 8, 2016·Accounts of Chemical Research·Bernhard WolfrumPhilipp Rinklin
Sep 3, 2009·Journal of the American Chemical Society·Marcel A G ZevenbergenSerge G Lemay
May 9, 2014·Physical Chemistry Chemical Physics : PCCP·Martin HüskeBernhard Wolfrum
Sep 8, 2011·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Sara E C DaleFrank Marken
Mar 28, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Carla R GarcíaJulia L Brumaghim
Nov 20, 2013·Nanoscale·Martin HüskeBernhard Wolfrum
Sep 16, 2017·Journal of Food and Drug Analysis·Kavitha PathakotiHuey-Min Hwang
Feb 3, 2011·Lab on a Chip·Boris HofmannBernhard Wolfrum
Oct 2, 2014·The Analyst·Sahana SarkarSerge G Lemay
Aug 28, 2014·Beilstein Journal of Nanotechnology·Enno KätelhönBernhard Wolfrum
Mar 16, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·R Lyle HoodAlessandro Grattoni
Mar 6, 2013·Angewandte Chemie·Yaqing LiuDirk Mayer
May 7, 2019·Microsystems & Nanoengineering·B X E DesbiollesP Renaud
Apr 30, 2010·The Journal of Physical Chemistry. B·Sang Yoon LeeShizhi Qian
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Aug 12, 2009·Analytical Chemistry·Michelle L Kovarik, Stephen C Jacobson
Sep 12, 2009·Analytical Chemistry·Marcel A G ZevenbergenSerge G Lemay
Jul 6, 2017·Analytical Chemistry·Magdalena KundysWojciech Adamiak
Jun 13, 2013·Journal of the American Chemical Society·Enno KätelhönBernhard Wolfrum

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