Nanoformulation of poly(ethylene glycol) polymerized organic insect repellent by PIT emulsification method and its application for Japanese encephalitis vector control

Colloids and Surfaces. B, Biointerfaces
A P B BalajiNatarajan Chandrasekaran

Abstract

The utilization of increased dosage of insect repellents to overcome mosquito resistance has raised environmental concerns globally. In accord to this, we have formulated an efficacious, water-dispersive, nanometric formulation of a poor water-soluble insect repellent, diethylphenylacetamide (DEPA) by poly(ethylene glycol) (PEG) polymerization followed by PIT emulsification method. The critical micelle concentration of PEG in the spontaneously emulsified conventional DEPA droplets was determined, based on the droplets physical stability. Subjecting them to PIT emulsification yielded monodispersed polymeric nanomicelles of DEPA (Nano DEPA) with hydrodynamic mean diameter of 153.74 nm. The high-resolution scanning and transmission electron microscopic studies revealed the characteristic core-shell structure of micelle. The comparative efficacy of Bulk DEPA and Nano DEPA was evaluated by larvicidal and WHO cone bioassay against the Japanese encephalitis vector Culex tritaeniorhynchus. The median lethal concentrations (48 h) for 3rd instars C. tritaeniorhynchus larvae were found to be 0.416 mg/L for Bulk DEPA and 0.052 mg/L for Nano DEPA, respectively. The median knockdown concentrations (60 min) for the two to three-day-old, sucro...Continue Reading

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Citations

Sep 27, 2015·Bulletin of Environmental Contamination and Toxicology·A P B BalajiNatarajan Chandrasekaran
Apr 12, 2016·Ecotoxicology and Environmental Safety·Jorge Werdin GonzálezBeatriz Fernández Band
Sep 28, 2016·Environmental Science and Pollution Research International·Prabhakar MishraNatarajan Chandrasekaran
Aug 10, 2019·PLoS Neglected Tropical Diseases·Taciano P FerreiraRaimundo W S Aguiar
Jun 6, 2017·Environmental Science and Pollution Research International·Jorge Omar Werdin GonzálezBeatriz Fernández Band
Nov 9, 2017·Environmental Science and Pollution Research International·Prabhakar MishraNatarajan Chandrasekaran
Mar 26, 2021·Malaria Journal·António B MapossaTaneshka Kruger
Apr 11, 2021·Tropical Medicine & International Health : TM & IH·Pedram EbrahimnejadAhmadali Enayati

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