NANOG regulates epithelial-mesenchymal transition and chemoresistance through activation of the STAT3 pathway in epithelial ovarian cancer

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Suqing LiuYunyan Sun

Abstract

NANOG is a key transcription factor that is overexpressed and plays an important role in various cancers. Its overexpression is associated with highly tumorigenic, drug-resistant, and poor prognosis. However, the underlying mechanism of action of NANOG in ovarian cancer remains unclear. Epithelial-mesenchymal transition (EMT), which is a critical process in cancer invasion and metastasis, is also associated with drug resistance. We determined whether NANOG is associated with EMT and chemoresistance in epithelial ovarian cancer cells. NANOG expression was increased in epithelial ovarian cancer cells (HEY and SKOV3) compared with normal epithelial ovarian cells (Moody). Low expression of NANOG increased the expression of E-cadherin and decreased the expression of vimentin, β-catenin, and Snail. Furthermore, the cell migration and invasion abilities were decreased. The multidrug resistance genes MDR-1 and GST-π were also downregulated when NANOG was lowly expressed. The cells that were transfected with the si-NANOG plasmid were more sensitive to cisplatin compared with the cells that were transfected with empty vector. The data demonstrated that Stat3 was correlated with NANOG-mediated EMT and drug resistance. The silencing of Sta...Continue Reading

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Citations

Aug 25, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yuan LiChangzhi Huang
Oct 18, 2016·Medicina·Raimonda KubiliūtėSonata Jarmalaitė
Jun 29, 2016·Biochemical Pharmacology·Michael F EmmonsKeiran S M Smalley
May 4, 2018·Journal of Cellular and Molecular Medicine·Ketao ZhangJianping Liu
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Aug 5, 2017·Journal of Cellular Physiology·Lei ZhaoBing Zhang
Sep 25, 2017·Oncotarget·Hua-Chuan Zheng
Sep 23, 2020·Journal of Cellular Physiology·Basira NajafzadehBehzad Baradaran
Mar 3, 2019·Journal of Experimental & Clinical Cancer Research : CR·Shanshan DongYong Zeng
Aug 10, 2019·World Journal of Stem Cells·Natasa Kenda Suster, Irma Virant-Klun
Jul 18, 2017·Molecular Medicine Reports·Tongfu FengYuanzhen Zhang
Sep 13, 2017·Scientific Reports·Juan P RodrigoJuana M García-Pedrero
Mar 7, 2021·International Journal of Molecular Sciences·Dinesh BhartiGyu-Jin Rho
Oct 1, 2018·Pharmacology & Therapeutics·Mohit Kumar JollyHerbert Levine
May 20, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Liyun LiuHou-Wen Lin
Dec 12, 2020·Drug Discovery Today·Po-Chang Shih, Kuo-Ching Mei

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