Nanoghosts as a Novel Natural Nonviral Gene Delivery Platform Safely Targeting Multiple Cancers

Nano Letters
Limor KanetiMarcelle Machluf

Abstract

Nanoghosts derived from mesenchymal stem cells and retaining their unique surface-associated tumor-targeting capabilities were redesigned as a selective and safe universal nonviral gene-therapy platform. pDNA-loaded nanoghosts efficiently targeted and transfected diverse cancer cells, in vitro and in vivo, in subcutaneous and metastatic orthotopic tumor models, leading to no adverse effects. Nanoghosts loaded with pDNA encoding for a cancer-toxic gene inhibited the growth of metastatic orthotopic lung cancer and subcutaneous prostate cancer models and dramatically prolonged the animals' survival.

References

Jan 1, 1986·Journal of Toxicology and Environmental Health·S T WolfordR Ruhren
Mar 29, 2001·Molecular Therapy : the Journal of the American Society of Gene Therapy·R RameshJ A Roth
Apr 20, 2002·Drug Discovery Today·Manfred Ogris, Ernst Wagner
Sep 1, 2004·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·R E NiksF Ordon
Apr 26, 2006·The Journal of Experimental Medicine·Aarif Y KhakooToren Finkel
Aug 19, 2007·Molecular Cancer Therapeutics·Maayan Duvshani-EshetMarcelle Machluf
Mar 12, 2009·Current Gene Therapy·Alex W TongJohn Nemunaitis
Mar 10, 2010·Cancer Investigation·Berber D RoordaEveline S J M de Bont
Apr 23, 2010·Cancer Metastasis Reviews·Scott A Bergfeld, Yves A DeClerck
Mar 3, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tomer BronshteinMarcelle Machluf
Apr 7, 2011·Nature Reviews. Genetics·Mark A Kay
Oct 6, 2011·International Journal of Oncology·Shinji TsukamotoYasuhito Tanaka
May 2, 2012·Journal of Hematology & Oncology·Shihua WangRobert Chunhua Zhao
Aug 4, 2012·Current Gene Therapy·Aisling J O'LoughlinMatthew J A Wood
Sep 5, 2012·Cell Communication and Signaling : CCS·Ralf Hass, Anna Otte
Feb 20, 2013·The Journal of Cell Biology·Graça Raposo, Willem Stoorvogel
Jun 22, 2013·Nano Letters·Naama E Toledano FurmanMarcelle Machluf
Jul 19, 2013·The Korean Journal of Internal Medicine·Nayoun Kim, Seok-Goo Cho

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Citations

Nov 16, 2017·Current Opinion in Organ Transplantation·Silvia MinardiXunrong Luo
Sep 6, 2017·Nanotechnology·Evgeniya GoldmanAvi Schroeder
Apr 24, 2017·Cellular and Molecular Life Sciences : CMLS·Andrea LolliRoberta Piva
Jul 4, 2018·International Journal of Molecular Sciences·Ángela ÁyenHouria Boulaiz
Feb 27, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yuancheng LiHui Mao
Jan 6, 2018·Cancer Research·Michael TimanerYuval Shaked
Dec 31, 2019·Nanomedicine : Nanotechnology, Biology, and Medicine·Qingguo ZhaoFei Liu
Dec 17, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hong-Hui WuJian-Qing Gao
Dec 4, 2019·Methods : a Companion to Methods in Enzymology·Jacopo OieniMarcelle Machluf
Jan 22, 2021·Cellular & Molecular Biology Letters·Wenqing LiangXuerong Chen
Mar 16, 2017·Biomaterials·Ronnie H FangLiangfang Zhang
Mar 21, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jacopo OieniMarcelle Machluf
Jul 8, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Reza MohammadinejadAli Zarrabi
Mar 20, 2021·International Journal of Pharmaceutics·Yuanqin SuJianqing Gao
Apr 9, 2021·Progress in Lipid Research·Alexsandra Conceição ApolinárioLuciana Biagini Lopes
Feb 24, 2019·Pharmacology & Therapeutics·Alexander M Cryer, Andrew J Thorley
May 21, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·D D'AtriMarcelle Machluf
Jun 21, 2021·Advanced Drug Delivery Reviews·Alice GrangierAmanda K A Silva
Apr 13, 2019·Accounts of Chemical Research·Zhaowei ChenZhen Gu
Sep 20, 2021·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Eran BlaugrundAlon Bloomenfeld
Jan 23, 2022·Journal of Nanobiotechnology·Wen LeiShibing Wang
Sep 9, 2020·Current Pharmaceutical Biotechnology·Mohammad SaeediSeyed N Hoseinian

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