Nanomaterial-Based Organelles Protect Normal Cells against Chemotherapy-Induced Cytotoxicity

Advanced Materials
Ruibo ZhaoRuikang Tang

Abstract

Chemotherapy-induced cytotoxicity in normal cells and organs triggers undesired lesions. Although targeted delivery is used extensively, more than half of the chemotherapy dose still concentrates in normal tissues, especially in the liver. Enabling normal cells or organs to defend against cytotoxicity represents an alternative method for improving chemotherapy. Herein, rationally designed nanomaterials are used as artificial organelles to remove unexpected cytotoxicity in normal cells. Nanocomposites of gold-oligonucleotides (Au-ODN) can capture intracytoplasmic doxorubicin (DOX), a standard chemotherapy drug, blocking the drug's access into the cell nucleus. Cells with implanted Au-ODN are more robust since their viability is maintained during DOX treatment. In vivo experiments confirm that the Au-ODN nanomaterials selectively concentrate in hepatocytes and eliminate DOX-induced hepatotoxicity, increasing the cell's capacity to resist the threatening chemotherapeutic milieu. The finding suggests that introducing functional materials as biological devices into living systems may be a new strategy for improving the regulation of cell fate in more complex conditions and for manufacturing super cells.

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Citations

Mar 9, 2019·Advanced Materials·Biao JinRuikang Tang
Jun 9, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Jiake LinRuikang Tang
May 30, 2020·Small·Edit BrodszkijBrigitte Städler
Nov 19, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Xiaomin QianBrigitte Städler
Feb 27, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Jiahui LuJingjing Li
Sep 5, 2019·ACS Central Science·Alexander F MasonLoai K E A Abdelmohsen
Aug 14, 2020·Nano Letters·Yun ChenShiyong Zhang
Nov 30, 2021·Gels·Xinyi ZhangJie Gao
Jan 13, 2022·Biomacromolecules·Carina AdeBrigitte Städler

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