Nanomaterials towards fabrication of cholesterol biosensors: Key roles and design approaches

Biosensors & Bioelectronics
Urmila Saxena, Asim Bikas Das

Abstract

Importance of cholesterol biosensors is already recognized in the clinical diagnosis of cardiac and brain vascular diseases as discernible from the enormous amount of research in this field. Nevertheless, the practical application of a majority of the fabricated cholesterol biosensors is ordinarily limited by their inadequate performance in terms of one or more analytical parameters including stability, sensitivity and detection limit. Nanoscale materials offer distinctive size tunable electronic, catalytic and optical properties which opened new opportunities for designing highly efficient biosensor devices. Incorporation of nanomaterials in biosensing devices has found to improve the electroactive surface, electronic conductivity and biocompatibility of the electrode surfaces which then improves the analytical performance of the biosensors. Here we have reviewed recent advances in nanomaterial-based cholesterol biosensors. Foremost, the diverse roles of nanomaterials in these sensor systems have been discussed. Later, we have exhaustively explored the strategies used for engineering cholesterol biosensors with nanotubes, nanoparticles and nanocomposites. Finally, this review concludes with future outlook signifying some chall...Continue Reading

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Citations

Jan 25, 2017·ACS Applied Materials & Interfaces·Sivaprasad Chinnakkannu VijayakumarBo Tan
Apr 21, 2017·Critical Reviews in Analytical Chemistry·Jan KloudaKarolina Schwarzová-Pecková
Feb 12, 2017·Biosensors & Bioelectronics·Xiao-Ting SunZhang-Run Xu
Nov 9, 2018·Journal of Immunoassay & Immunochemistry·Liliana-Roxana BalahuraHassan Y Aboul-Enein
Oct 11, 2017·Nanoscale·Christopher M SimsBryant C Nelson
Jun 1, 2019·Biomedical Optics Express·Santosh KumarBingyuan Zhang
Mar 28, 2021·Mikrochimica Acta·Shiana MalhotraRenee V Goreham
Aug 16, 2017·ACS Applied Materials & Interfaces·Finizia AuriemmaAngela Lombardi
Nov 24, 2021·Chemical Communications : Chem Comm·Neha ThakurTharamani C Nagaiah

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