Nanomechanical characterization of red blood cells using optical tweezers.

Journal of Materials Science. Materials in Medicine
C Li, K K Liu

Abstract

Deformation behaviours of red blood cells (RBCs) have been studied by applying stretching forces via optical tweezers. Combined with finite-element analyses (FEA), the RBCs' mechanical properties are determined quantitatively based on a best fitting between the experimental deformed geometries and the simulated counterparts. Experimentally, a silica beads attached erythrocyte is optical-mechanically stretched to different lengths. On the theoretical front, a large deformation model with Mooney-Rivlin constitutive equations has been simulated by using FEA to predict the cell deformation geometries. The numerically simulated transverse and longitudinal strains which are in a good agreement with the experimental measurements facilitate the determination of elastic constants of the cells.

References

Jan 1, 1994·Annual Review of Biophysics and Biomolecular Structure·K Svoboda, S M Block
Jul 1, 1997·Journal of Structural Biology·U G HofmannM Radmacher
Nov 25, 1997·Biophysical Journal·G K RagsdaleK Luby-Phelps
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·C RotschM Radmacher
Jul 21, 2001·Biophysical Journal·J GuckJ Käs
Feb 8, 2002·Nature·Louis H MillerOgobara K Doumbo
Aug 15, 2003·Nature·David G Grier
Nov 22, 2005·Expert Opinion on Drug Delivery·Luiga RossiMauro Magnani

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Citations

Aug 8, 2012·Proceedings of the National Academy of Sciences of the United States of America·Christian SiebenAndreas Herrmann
Jun 7, 2011·Journal of Biomedical Optics·Ashis Gopal BanerjeeSatyandra K Gupta
Nov 10, 2009·Ageing Research Reviews·Maria N Starodubtseva
Nov 8, 2014·Biomicrofluidics·Puja MishraPeter Glynne-Jones

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