Nanomechanical mapping helps explain differences in outcomes of eye microsurgery: A comparative study of macular pathologies

PloS One
Gabriele CiascaAngelo Maria Minnella

Abstract

Many ocular diseases are associated with an alteration of the mechanical and the material properties of the eye. These mechanically-related diseases include macular hole and pucker, two ocular conditions due to the presence of abnormal physical tractions acting on the retina. A complete relief of these tractions can be obtained through a challenging microsurgical procedure, which requires the mechanical peeling of the internal limiting membrane of the retina (ILM). In this paper, we provide the first comparative study of the nanoscale morphological and mechanical properties of the ILM in macular hole and macular pucker. Our nanoscale elastic measurements unveil a different bio-mechanical response of the ILM in the two pathologies, which correlates well to significant differences occurring during microsurgery. The results here presented pave the way to the development of novel dedicated microsurgical protocols based on the material ILM properties in macular hole or pucker. Moreover, they contribute to clarify why, despite a common aetiology, a patient might develop one disease or the other, an issue which is still debated in literature.

References

Jan 8, 2004·Annals of Medicine·Donald E Ingber
May 10, 2007·The FEBS Journal·Joseph CandielloHai Lin
Dec 6, 2007·Survey of Ophthalmology·Aachal Kotecha
May 6, 2008·Biophysical Journal·Julia SchmitzKay-Eberhard Gottschalk
Feb 7, 2009·Nature Nanotechnology·M Lekka, P Laidler
Jul 6, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Celimar Valentín-RodríguezAlbena Ivanisevic
Sep 28, 2010·Trends in Cell Biology·Hongmei YuValerie M Weaver
Apr 12, 2011·Journal of Surgical Oncology·Harold F DvorakGabriele Bergers
Apr 22, 2011·Nature Reviews. Molecular Cell Biology·Christopher C DuFortValerie M Weaver
Jan 3, 2012·Archives of Biochemistry and Biophysics·Małgorzata LekkaPiotr Laidler
Mar 14, 2012·Investigative Ophthalmology & Visual Science·Paul B HenrichMarko Loparic
Sep 7, 2012·Retina·Richard F Spaide
Sep 18, 2013·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Paul B HenrichUNKNOWN International Chromovitrectomy Collaboration
Oct 12, 2013·Proteomics. Clinical Applications·Vinit B Mahajan, Jessica M Skeie
Dec 21, 2013·Journal of Biomechanical Engineering·Ian C CampbellC Ross Ethier
Oct 31, 2014·Nature Reviews. Molecular Cell Biology·Jay D HumphreyMartin A Schwartz
Aug 25, 2015·The FEBS Journal·Willi HalfterMarija Plodinec
Sep 14, 2016·World Journal of Gastroenterology : WJG·Gabriele CiascaMarco De Spirito
Nov 18, 2016·Nanoscale·Gabriele CiascaMarco De Spirito
Jul 27, 2017·Seminars in Cell & Developmental Biology·Jordi AlcarazDaniel Navajas
Mar 1, 2018·Annual Review of Analytical Chemistry·Anisha N Patel, Christine Kranz
Sep 1, 2018·Nano Letters·Cécile FeuillieYves F Dufrêne
Mar 29, 2019·International Journal of Legal Medicine·Fabio De-GiorgioGabriele Ciasca

❮ Previous
Next ❯

Methods Mentioned

BETA
Atomic Force Microscopy
AFM

Software Mentioned

OriginPro
ImageJ Editor
JPK
ImageJ
Excel

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye
Ozay OzAkduman Levent
Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Ko NakataYasuo Tano
© 2021 Meta ULC. All rights reserved